5th December 2022
Aetiology and Outcomes of Thrombocytopenia in Pregnancy: A Cross-Sectional Study in a University Hospital, India
Thrombocytopenia (TCP) is the second most common haematological finding in pregnancy next to anaemia. It carries a risk for both the mother and the fetus, associated with substantial maternal or neonatal morbidity and mortality. However, a specific therapy, if instituted promptly, improves the outcome for affected patients and their offspring. In patients in India, TCP during pregnancy is an underexplored condition.
2nd December 2022
EGFR-Mutant Non-small Cell Lung Cancer: State-of-the-Art and Future Perspectives
Epidermal growth factor receptors (EGFR), the first of four members of the ErbB family, play essential roles in both normal physiological and cancerous conditions. EGFR is characterised by an extracellular ligand-binding domain, which when activated by the ligand leads to the receptor dimerisation; a transmembrane domain, responsible for the dimerisation; and an intracellular tyrosine kinase domain that activates the intracellular kinase domain and the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptor.
1st December 2022
Gastric Pouch Gastrointestinal Stromal Tumour Post-Roux-en-Y Gastric Bypass: A First Reported Case
Gastric gastrointestinal stromal tumour is an extremely rare condition to occur after bariatric surgery. To the authors’ knowledge, only two cases of gastric gastrointestinal stromal tumours after Roux-en-Y gastric bypass have been reported in the medical literature, both occurring in the excluded gastric remnant. Herein, the authors report the third case of gastric gastrointestinal stromal tumour post-Roux-en-Y gastric bypass, and the first case to occur in the gastric pouch, which was managed surgically by laparoscopic resection. From here, combining the observations of clinicians treating and following up patients post-bariatric surgery in an international database will be beneficial to patients, and aid in development of surveillance guidelines.
1st December 2022
Infographic: Perceptions of Treatments in AML – A Survey of 375 European Haematologists
Acute myeloid leukaemia (AML) is a rapidly progressing haematological cancer with a poor prognosis. This infographic summarises the key results from an online survey conducted in 2022 on the perceptions of AML treatments among clinicians in Europe. Haematologists and oncologists from five European countries were asked their opinions on topics such as first-line treatments, the intensity of treatment regimens, and therapies for curative intent for patients with AML.
22nd November 2022
Infographic: Systemic mastocytosis (SM) is a rare form of mast cell disorder characterised by abnormal proliferation and activation of mast cells
Systemic Mastocytosis Disease Awareness Infographic: Learn more about this rare disease, its prevelance, symptoms, sub-types and diagnosis.
22nd November 2022
Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron Wave
Since the detection of the first cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant causing COVID-19 infections in South Africa in November 2021, there have been a few population-based reports to suggest that the clinical severity and presentation of this variant is different to previous COVID-19 surges. This variant is known to have several mutations to previous variants of this virus; hence, it was predicted to be much more infectious due to possible immune evasion.
21st November 2022
A 3D-Printed Ultrasound Task Trainer for the Practice of Hip Joint Injections
Ultrasonography is often the preferred method of imaging for needle-guided procedures of the hip joint, including aspirations, local anaesthetic injections, and the use of corticosteroids. Phantoms (i.e., training devices mimicking human tissue and bony structures under acoustic sonography) are used to help train medical professionals to perform these procedures accurately, emphasising the art of physical simulation in unison with didactic learning.