News

Melatonin supplementation reduced inflammation and improved lipid profiles in children undergoing chronic haemodialysis, suggesting potential cardiovascular and antioxidant benefits.

The system has been made available online, potentially enabling healthcare providers to rapidly assess CMM risk in patients with T2DM and implement timely interventions to slow disease progression.

Real-world data from TriNetX show patients with rheumatoid arthritis have a significantly increased risk of thyroid cancer, highlighting the need for awareness and surveillance.

A randomized controlled trial shows high-intensity interval and strength exercise improves multidimensional fatigue and quality of life in people with rheumatoid arthritis, with benefits lasting 12 months.

The study found sustained improvements across all exploratory measures, including anxiety, insomnia, and post-traumatic stress symptoms.

A propensity-weighted study compares micro-ultrasound with MRI fusion biopsy for detecting clinically significant prostate cancer in men with MRI-visible lesions.

Machine learning analyses everyday WhatsApp voice notes to detect depressive profiles with high accuracy in real world settings.

Early haematopoietic stem cell transplantation after liver transplantation resulted in 90% survival in children with hepatitis-associated aplastic anaemia, with normal blood counts and liver function at follow up.

UK Biobank study links very low vitamin D levels with higher risk of hospital admission for respiratory tract infections across ethnic groups.

Researchers are debating whether ERAP2 can serve as a reliable ageing-derived biomarker for premature ovarian insufficiency, reflecting underlying biological ageing.

Elevated pallidal beta power may serve as a biomarker for depression in Parkinson’s disease, paving the way for targeted DBS therapies. Learn more.

Acne risk rises sharply in transmasculine individuals starting testosterone and also affects transfeminine patients on estradiol. Read more.

Discover why deep brain stimulation may be safer than expected and how large scale data could change surgical decision making.

Machine learning models accurately predict survival after surgery for upper tract urothelial cancer, supporting personalised follow up and adjuvant treatment decisions.

New sero-genomic research suggests hidden mpox exposure in healthy Nigerian adults, highlighting residual smallpox immunity and surveillance gaps.

A first clinical study suggests allogeneic CD19-targeted CAR-T cell therapy can safely induce durable remission in patients with severe, treatment-refractory systemic lupus erythematosus.

Hetrombopag achieved an overall response in over three quarters of paediatric patients with immune thrombocytopenia, with durable responses and no serious adverse events reported.

MPO concentrations in selectively drained pericardial fluid were 25-fold higher than mixed drainage samples and 1,648-fold higher than serum levels (both p

Sphingolipid-to-steroid ratios in blood accurately predict asthma attacks years in advance, offering a new precision medicine tool for asthma care.

New research suggests shingles vaccination may slow biological ageing and reduce inflammation, supporting healthier ageing beyond infection prevention.

Low baseline ctDNA and early clearance during treatment are strongly associated with improved response and survival in advanced breast cancer, highlighting ctDNA as a promising predictive and surrogate biomarker.

Early gut microbiota changes may predict diabetes, recurrence, and mortality after acute pancreatitis, offering new tools for long-term risk assessment.

New research suggests a blood-based test could improve early detection of liver cancer in high-risk patients.

Ultra-high-field 5 T MRI delivers improved image quality and diagnostic accuracy compared with 3 T MRI for prostate cancer, according to a prospective intra-individual study.

Exclusive breastfeeding for at least four months was associated with lower overall odds of asthma up to age 24 years (odds ratio: 0.75; 95% CI: 0.64–0.87).

UK Biobank data show people with rheumatoid arthritis have higher risks of heart disease, heart failure, and arrhythmias, with genetic analyses supporting causal links.

Urinary cell-free microRNAs may enable non-invasive detection of aggressive bladder cancer subtypes, offering a rapid alternative to tissue-based molecular profiling.

A nationwide Swedish study links long-term air pollution exposure to increased motor neuron disease risk and poorer outcomes.

RBC immunization affects over 14% of transfused patients with myelodysplastic syndromes and is independently associated with markedly reduced survival, highlighting its emerging prognostic relevance.

Teens with obesity using GLP-1RAs experienced fewer asthma exacerbations, emergency visits, and steroid prescriptions compared with nonpharmacological weight management.

Doctors warn that screen use and harmful online content may be damaging children’s health, as the UK considers restricting social media access for under-16s.

Overexpression of hsa-miR-339-5p suppressed NLRC5, activated the PI3K/Akt signalling pathway, and significantly increased type 1 collagen and α-smooth muscle actin expression, indicating enhanced fibrotic remodelling.

Real-world data from Italy show high two-year drug survival and sustained disease control with bimekizumab in moderate-to-severe plaque psoriasis.

A global meta-analysis shows people with mental disorders receive poorer diabetes monitoring and less access to newer therapies.

New data show that deep-learning classifiers can accurately identify key driver alterations in non-small cell lung cancer…

Universal infant nirsevimab prophylaxis significantly reduced RSV-related hospitalisations and outpatient visits across two seasons in Spain.

New data show that alcohol-related liver disease continues to drive liver mortality, even where overall alcohol consumption has declined.

A first-in-human pilot trial suggests umbilical cord–derived mesenchymal stem cell eye drops may safely improve symptoms and inflammation in refractory dry eye, including Sjögren’s syndrome.

A major review links PFAS exposure to higher gestational diabetes risk, highlighting environmental chemicals as emerging pregnancy health concerns.

Londamocitinib produced approximately 50% reductions in fractional exhaled nitric oxide at the 1.4 mg and 3 mg doses.

Randomised trial shows chiropractic care alters stress, immune, and neuroplasticity biomarkers in adults with spinal pain.

Early urine output patterns in female ICU patients with genitourinary infections are strongly linked to 28-day mortality and acute kidney injury risk.

Long-term trial data show vagus nerve stimulation sustains and even increases benefits for patients with severe treatment resistant depression.

The ESCORT-HU and ESCORT-HU Extension studies followed 3,145 patients, with 1412 (45%) men and 1733 (55%) women….

Expanded school tobacco prevention in California schools was linked to lower adolescent tobacco use in a large, state-representative survey.

New data show that many women do not receive effective contraception in the postpartum period, highlighting missed opportunities in reproductive healthcare.

AI echocardiography using multimodal right ventricular assessment predicted mortality in pulmonary hypertension.

A birth cohort study reveals how genetics, environment, and hygiene shape the infant skin microbiome and its early links to atopic dermatitis.

When combined with conventional MEP data, the model achieved 83.3% overall accuracy and 82.3% balanced accuracy in identifying MDD.

Key cell cycle genes have been identified as prognostic biomarkers in nasopharyngeal carcinoma, enabling a new prediction model that integrates gene expression with clinical factors to improve survival estimation.

High cannabis use is associated with worse lung function, respiratory symptoms, and airway immune changes, highlighting potential clinical risks.

New research suggests that abnormal sleep duration may be associated with increased risk of chronic liver disease, particularly in people with metabolic risk factors.

New stainless steel neural probes promise safer deep brain sensing, reducing fracture risk while supporting high-resolution recordings for research and surgery.

The researchers found that carotid plaque volume derived using the hemi-ellipsoid approach provided a more sensitive tool for evaluating plaque severity and monitoring progression over time compared with diameter or area stenosis alone.

A preliminary study suggests a plant-based low-protein diet may improve metabolic and inflammatory parameters and help prevent malnutrition–inflammation complex syndrome in adults with CKD.

Among 469 circulating metabolites assessed, 235 were significantly associated with incident disease. Notably, 67 of these associations had not been previously reported.

Statistical analysis using Cox proportional hazards models demonstrated a significantly increased hazard of colorectal cancer associated with psychiatric disorders (hazard ratio: 1.93; 95% CI: 1.64–2.27).

A 12-year follow-up study shows urinary symptoms worsen over time after vaginal delivery, but long-term severity and quality-of-life impact are similar with or without OASIS.

Machine learning analysis reveals why cancer survival differs between countries, identifying radiotherapy, coverage, and economic factors as critical drivers.

Individuals with large spleens face increased risk of hematologic cancer and liver disease, supporting the use of spleen size thresholds in clinical assessment.

Rising pTau-181 after COVID-19 correlates with neurological post-acute sequelae, offering clinicians potential prognostic insight.

Updated guidance highlights persistent gaps in endometriosis diagnosis and care, calling for earlier recognition and more integrated reproductive health services.

Cytokine profiling demonstrated that a dose of 2,000 mg/kg/day elicited the most robust protective response, significantly reducing markers of neuroinflammation.

Real-world registry data from Germany show apremilast improves psoriasis severity and quality of life, with a safety profile consistent with clinical trials.

Find out how maternal diabetes and birth size may shape multiple sclerosis risk decades later in adulthood across large national cohorts.

New guidelines update ART choices, endorse long-acting injectables, refine infant feeding advice, and prioritise shorter TB preventive regimens.

A new global report shows uneven progress towards viral hepatitis elimination, with major gaps in diagnosis and treatment contributing to ongoing liver-related deaths.

Volumetric non-invasive cardiac mapping reduced geodesic localisation error by 59.3% compared with surface-only approaches, demonstrating substantially improved accuracy in identifying arrhythmia origins.

New data show that many women lack access to preconception health advice, highlighting missed opportunities to improve reproductive and pregnancy outcomes.

New data show hip osteoarthritis does not raise the risk of immune checkpoint inhibitor–induced inflammatory arthritis, while ICI-related arthritis is linked to improved survival.

A large network meta-analysis finds dual therapy for Helicobacter pylori offers comparable eradication rates with fewer side effects and better compliance than triple or quadruple regimens.

Altered serum and urinary bile acids were identified in patients with advanced chronic kidney disease, with specific bile acids associated with declining kidney function.

Real-world data suggest lebrikizumab delivers sustained clinical and quality-of-life improvements in patients with moderate-to-severe atopic dermatitis.

In patients with non-obstructive coronary artery disease, use of IMRCT reduced CMD underdiagnosis rates from approximately 35–39% to below 6%.

PSA derivatives may help reduce unnecessary prostate MRI in men with prior negative biopsy, while maintaining detection of clinically significant cancer.

Meta-analysis links prior tuberculosis and chronic bronchitis to higher lung cancer risk in never-smokers, with implications for clinical risk assessment.

The new analysis draws on the prospective MALRIC study, including patients treated between 2009 and 2024 across 10 hospitals

A hospital pilot suggests video-based patient records support frailty assessment, yet staff engagement remains limited despite promising patient-centred care benefits.

A new genetic classification integrating co-mutations significantly refines risk stratification in NPM1-mutated AML and may guide allogeneic transplant decisions in first complete remission.

Large cohort study links higher exposure to several food preservatives with increased type 2 diabetes incidence, prompting calls for safety review.

Importantly, this microbiota–metabolite signature was inversely associated with the development of food allergen-specific IgE up to 5 years of age and with atopic dermatitis at 2 years.

New research has identified a liver-specific receptor, GPR110, as a key driver of sex-related differences in the progression of metabolic dysfunction-associated steatohepatitis.

The results showed that patients receiving the STDP experienced significant reductions in CTFC in both the left anterior descending artery and left circumflex artery (both p

A nationwide study reveals that pregnancy acid-suppressive medication does not increase children neuropsychiatric disorder risk over time.

Tirzepatide initiation in type 2 diabetes mellitus was associated with a significantly lower risk of primary open-angle glaucoma, ocular hypertension, and need for glaucoma treatment compared with selective glucagon-like peptide-1 receptor agonists.

An all oral iberdomide based combination achieved a median progression free survival of 17.6 months in heavily pretreated patients with relapsed and refractory multiple myeloma.

Real-world data show how microbiological findings and patient factors can guide empirical antibiotic choice in acute cholangitis, supporting carbapenem-sparing strategies in selected patients.

Expansion of antiretroviral therapy in Uganda sharply reduced orphanhood incidence, especially among adolescents, but substantial risk persists.

ERA Registry data show rising kidney replacement therapy incidence and prevalence across Central and Eastern Europe, with wide national variation and limited COVID-19 impact.

After adjusting for established cardiovascular risk factors, each standard deviation increase in LOY was associated with a 14% higher risk of myocardial infarction.

SGLT2 inhibitors may slow prostate cancer progression in men on hormone therapy, reducing therapy failure. Find out how these diabetes drugs could help.

Therapist-guided internet CBT safely lowers asthma-related anxiety and boosts quality of life, control, and behaviour in adults with asthma.

Recreational substance use is associated with a broad range of neuroimaging findings, and radiologists play a key role in recognising patterns that influence emergency management and prognosis.

Long-term research links Mediterranean diet patterns with lower Parkinson’s incidence in women younger than seventy one years.

Baseline fatigue reported at treatment initiation is associated with a significantly increased risk of severe, life threatening, and fatal cancer treatment related toxic effects.

Evidence from a clinical trial and long-term cohort studies suggests metformin, widely used in diabetes, may reduce knee osteoarthritis pain and lower future osteoarthritis risk.

ALA-DAG oil improved skin hydration and reduced allergic symptoms in adults with mild skin discomfort.

A new systematic review found associations between alterations in the reproductive tract microbiota and miscarriage risk, with potential implications for reproductive health.

Real-world data show distinct determinants of health-related quality of life in Crohn’s disease and ulcerative colitis, highlighting phenotype-specific roles of inflammation, imaging findings, treatment burden, and modifiable risk factors.

Across medium- and long-term follow-up, no patients developed valve stenosis or severe pulmonary regurgitation.

A large genomic study shows that most psychiatric disorders share common genetic factors, questioning traditional diagnoses and pointing towards a more neurobiologically grounded approach to mental illness.

A recent perspective highlights challenges in translating human microbiome research into consistent clinical benefits and precision interventions.

Lower dietary antioxidant intake is linked to higher oxidative stress in rosacea, with potential implications for disease severity and clinical management.

A 1000 ng/mL D-dimer threshold safely rules out pulmonary embolism in low-likelihood patients, reducing unnecessary chest imaging in emergency care.

A machine learning lung cancer risk model showed improved accuracy over traditional methods, with potential to enhance patient selection for radiology based lung cancer screening.

Very high lipoprotein(a) predicts decades of cardiovascular risk, guiding screening, personalised prevention, and earlier clinical intervention for women.

Perioperative nivolumab significantly improved survival and pathological response in stage III non-small-cell lung cancer, challenging the traditionally poor prognosis associated with N2 nodal disease.

Mazdutide, a dual glucagon and GLP-1 agonist, delivers greater HbA1c and weight reductions than dulaglutide in people with type 2 diabetes.

Across these trials, anti-inflammatory treatment significantly reduced anhedonia, defined as reduced capacity to experience pleasure, with a moderate effect size.

A national cohort study shows rheumatoid arthritis remission rates in England and Wales have plateaued since 2018, with wide regional variation and delays before specialist referral limiting progress

New research calls for routine risk stratification of MASLD in people with obesity to detect and manage liver disease earlier.

A target trial emulation study finds no relapse reduction with cyclophosphamide added to glucocorticoids in eosinophilic granulomatosis with polyangiitis without poor-prognosis factors.

Find out how robot-assisted therapy for autism matches standard treatment outcomes while improving engagement and expanding access in clinical and community settings.

A recent study links chemotherapy to impaired ovarian function and fertility through oxidative damage to ovarian follicles.

Randomised trial shows intravenous iron significantly improves maternal haemoglobin before delivery in non-anaemic iron deficient pregnancy, supporting ferritin screening and targeted treatment in antenatal care.

Pooled trial data show gepotidacin provides early, meaningful symptom relief comparable to nitrofurantoin in uncomplicated urinary tract infection.

Meta-analysis shows neutrophil to lymphocyte ratio is associated with higher risk and progression of diabetic nephropathy, supporting its potential use as an inflammatory biomarker in clinical practice.

Real-world Danish registry data show that biologic drug survival in psoriasis differs between biologic-naive and bioexperienced patients.

A major UK trial launched to screen up to 42,000 adults in primary care for early liver disease using non-invasive testing.

A qualitative study reveals how trust, communication, and clear responsibility between doctors influence vaccination uptake in patients with inflammatory rheumatic and musculoskeletal diseases.

Higher cardiovascular risk may signal increased likelihood of eye disease. Find out more about protecting long-term eye health.

A new study found that rare emotional and physical symptoms occurring during orgasm are uncommon but fall within the normal range for women.

Using large public datasets including TCGA, GEO and GTEx, researchers found that BAZ2B expression was consistently reduced in several cancer types, with particularly marked downregulation in breast cancer.

In a multivariate Cox proportional hazards model, statin therapy was associated with a 52% relative reduction in the risk of death at 30 days.

Adjunctive vitamin D may improve pain, healing, and inflammation in oral lichen planus, with benefits most evident during the first six weeks of treatment.

Adaptive ECG noise filtering preserved QT and QRS intervals better than conventional approaches by tailoring filters to noise presence and type.

A new meta-analysis links elevated neutrophil-to-lymphocyte ratio to higher risk and progression of diabetic nephropathy, highlighting its potential as a clinical biomarker.

Combining a host biomarker with large language model analysis improves lower respiratory tract infection diagnosis in ICU patients, reducing uncertainty.

Axillary ultrasound and MRI guide SLNB decisions in early-stage breast cancer, allowing safe surgical de-escalation in selected clinically node-negative patients.

Find out how an electronic diary improves monitoring of gastroesophageal reflux disease symptoms, and supports personalised management strategies for patients.

Daratumumab-lenalidomide maintenance enhances MRD-negative conversion and reduces progression in multiple myeloma patients regardless of age, race, or cytogenetic risk.

PUFA-rich and Nordic diets reduce liver fat and LDL cholesterol over 12 months, with broader metabolic benefits seen with the Nordic diet.

After 1 year, 13 of 17 patients in the 30 mg group tolerated at least 443 mg peanut protein, compared with none in the avoidance group. Similar improvements were observed in the 300 mg group.

Molecular profiling and matched targeted treatment significantly improved survival in advanced cholangiocarcinoma in a large Italian real-world study.

New data identify age, anti-β2GP1 antibodies, and low C3 as key risk factors for cerebral small vessel disease in systemic lupus erythematosus, highlighting the need for targeted screening and risk stratification.

The results suggest that treatment once weekly with semaglutide could reduce the frequency and duration of hospital admissions for patients at high cardiovascular risk…

In 2026, the beleaguered, aging National Health Service (NHS) of England is on the precipice of major changes in staffing models and digital implementations.

An optimised OFA/iLRP aptamer forms a DNA nanostructure delivering doxorubicin selectively to AML cells, improving efficacy and reducing toxicity in preclinical models.

Children facing economic instability and poor social support in the USA have higher odds of long COVID, highlighting the role of social determinants in child health.

39 studies involving 14 300 participants showed that patients with diabetic nephropathy had significantly elevated NLR levels compared to diabetic controls without nephropathy.

An increased polygenic score for HCM was associated with an 1.1% increase in left ventricular ejection fraction…

NHS opt-out tobacco dependency services boost quit attempts in deprived populations, but success lags, highlighting opportunities to reduce inequalities.

New research shows blood age can directly influence Alzheimer’s progression and memory decline in experimental models.

AI system surpasses radiologists in detecting pancreatic cancer on CT scans, promising earlier diagnosis and better outcomes.

Global modelling study shows the economic burden of diabetes could reach trillions by 2050, with informal caregiving a major, under-recognised cost driver.

Autoclaving peanuts significantly reduces IgE binding and improves tolerability in peanut-allergic individuals, offering promise for safer immunotherapy approaches.

Higher baseline testosterone and favourable testicular histology independently predict sperm retrieval success in men with nonmosaic Klinefelter syndrome undergoing TESE.

Impaired heart rate recovery is a powerful new marker for predicting periprocedural myocardial infarction in elective PCI patients.

A university-based study finds a high prevalence of fibromyalgia symptoms, strongly linked to anxiety, stress, and lifestyle factors among students and staff.

New research shows social isolation directly speeds up cognitive decline across all demographic groups in older adults.

Telling women they have dense breasts increased anxiety and confusion without improving understanding or screening intentions.

Delayed routine infant vaccinations strongly predict missed MMR doses by age 2, raising concern as post-pandemic declines coincide with rising measles cases in the USA.

A decade-long retrospective study shows IgG4-related cholangitis responds well to steroids, with low mortality and no progression to cholangiocarcinoma.

Spatial proteomics analysis shows tertiary lymphoid structures correlate with immunotherapy response and survival in Merkel cell carcinoma.

New research shows EEG and AI can rapidly distinguish major dementia types.

Plasma presepsin outperformed traditional biomarkers in predicting 28-day mortality among patients with UTI-related severe infection in emergency care.

Medication-induced deep sedation in ICU patients is linked to loss of independence; lighter sedation and mobility improve outcomes, study finds.

The device, referred to as hPAM TUT, has a rigid body measuring 90 mm in length and just 17 mm in diameter, making it suitable for handheld use.

New research links contraceptive use, mental health and differing heart risk profiles in women.

Prostate cancer remains the most common cancer in men in the UK, with around 55,000 new cases and 12,000 deaths each year and is currently the most common cancer without a national screening programme.

A novel iPSC-derived lung-on-chip model mimics human alveolar tissue, revealing macrophage-driven tuberculosis responses.

After the first embryo transfer, 48.4% of couples in the preimplantation genetic testing group and 46.2% in the no testing group achieved a live birth, a difference that was not statistically significant.

Patients who survive colorectal cancer face a sustained and increased risk of death from chronic liver disease and cirrhosis long after surgery, according to a large population-based analysis from the United States.

New research shows how portable monitoring could reshape infant seizure diagnosis and treatment in neonatal intensive care.

The authors conclude that recognising postpartum haemorrhage at lower blood loss volumes, alongside abnormal haemodynamic signs, could support earlier diagnosis and treatment…

Researchers have identified serine threonine kinase 10 as a key regulator of platelet function, haemostasis and thromboinflammation.

Adult bacterial meningitis continues to carry high mortality and neurological complications, especially from Listeria, Streptococcus pyogenes, and pneumococcus.

Kidney transplant recipients from socioeconomically disadvantaged neighbourhoods face important inequalities in cancer risk and outcomes…

A large Mendelian randomisation study reveals that higher BMI and IBD causally increase hidradenitis suppurativa risk, providing actionable insights for dermatologists and patient counselling.

The basophil activation test may help identify children at risk of severe allergic reactions to cow’s milk, improving safety during oral food challenges.

A retrospective study identifies clinical, laboratory, and imaging predictors of sepsis and mortality after nephrostomy tube placement in cancer patients.

The NHS has introduced routine chickenpox vaccination using the combined MMRV jab, protecting young children from varicella and reducing illness, hospitalisations, and family disruption across the UK.

CT is one of the most widely used diagnostic imaging tools, but accurately estimating patient radiation dose remains challenging because of wide variation in body size and anatomy.

New meta-analysis confirms symbol coding tasks remain among the most impaired cognitive tests in schizophrenia.

Researchers have identified chromosomal instability in circulating tumour cells as a prognostic and predictive biomarker in metastatic castration resistant prostate cancer.

Global and genetic analyses link low physical activity to rising heart disease mortality, while higher activity levels appear to reduce myocardial infarction risk.

A 10-year hospital study reveals how often prediabetes progresses to type 2 diabetes, and how early intervention can reverse risk.

Elevated serum lipoprotein(a) levels are linked to poorer survival outcomes in pancreatic cancer, highlighting its potential as a stable prognostic biomarker.

Integrated structural and functional MRI identifies brain-based biomarkers that distinguish active from remissive Crohn’s disease and correlate with gut inflammation.

Adjunctive NB-UVB phototherapy improved disease control in chronic plaque psoriasis patients with secondary loss of response to adalimumab.

A Japanese cohort study has identified distinct liver enzyme trajectories in early adulthood that are strongly associated with the risk of developing type 2 diabetes.

New data show that minipuberty hormone levels in Turner syndrome can signal early ovarian function, supporting more informed fertility counselling in infancy.

At ASH 2025, investigators reported early results from the first-in-human phase 1 inMMyCAR study evaluating KLN-1010, an investigational in vivo gene therapy…

New evidence shows human rhinovirus can directly infect the lower lungs and cause pneumonia in adults, challenging its reputation as a mild cold virus.

Tai chi may improve long-term sleep in middle-aged and older adults with chronic insomnia, providing a safe and accessible alternative to CBT-I.

The incidence of early-onset colorectal cancer has been increasing worldwide, a trend that has coincided with growing intake of ultraprocessed foods.

Among patients treated in the first-line setting, the overall response rate was 57.1%, compared with 38.1% in those treated in the second line or later.

Genetic analysis shows higher BMI increases hidradenitis suppurativa risk, while smoking evidence is inconclusive. The study also supports a causal link with IBD.

Starting dialysis with a less intensive schedule may help preserve remaining kidney function without increasing risks, according to a new study comparing dialysis approaches.

A Canadian real-world study reveals high oral corticosteroid exposure in patients with severe chronic rhinosinusitis with nasal polyps prior to biologic therapy.

A large retrospective study shows GnRH antagonist protocols yield more oocytes than PPOS in young women at high risk for low retrieval.

Canadian patients with hereditary angioedema report reduced anxiety, fewer attacks, and improved quality of life with long-term subcutaneous C1 inhibitor therapy.

Access to blood transfusions emerged as the most highly valued service, with a mean standardised importance score of 20.53.

Baseline eosinophil levels and early blood count changes may help predict survival and response in metastatic renal cell carcinoma patients treated with nivolumab.

Ants produce diverse, targeted antimicrobial compounds that inhibit drug-resistant pathogens, including Candida auris, offering insights for new antibiotics.

Researchers have developed a new prediction tool that could help clinicians better assess whether complete tumour removal is achievable in women with advanced epithelial ovarian cancer.

A multi-omics study identifies causal genes and biological subtypes of Long COVID, revealing new therapeutic targets for personalised care.

Rare inherited genetic variants linked to mucin glycosylation and DNA repair significantly increase familial lung cancer risk, offering new targets for early detection.

A proof-of-concept trial shows novel sarcoidosis PET/CT tracer detects inflammatory activity, supporting further clinical evaluation.

New real-world data suggest 5:2 intermittent fasting may offer modest cardiovascular benefits over calorie restriction in adults with overweight or obesity.

Meta-analysis shows diabetes increases male infertility risk, with inflammation identified as a key underlying mechanism.

A large study found fewer mental health and cardiovascular events following the autumn daylight saving time clock change in England.

By broadening definition of success to include sustained low-level HBsAg with suppressed HBV DNA, we can recognize clinically meaningful responses that improve patient outcomes, even without full antigen clearance.

The study included 202 adults undergoing cardiac surgery at 11 Australian tertiary hospitals between August 2021 and April 2024.

New research identifies age, anti-β2GP1 antibodies, and low complement C3 as key risk factors for cerebral small vessel disease in systemic lupus erythematosus.

Lower ovarian reserve was significantly associated with accelerated pace of aging and higher methylation risk scores for cardiovascular and metabolic disease.

Vixarelimab significantly reduced itch severity and improved skin clearance in patients with prurigo nodularis in a phase 2b randomized clinical trial.

International panel of anaphylaxis experts develops guidance for non-medical personnel to correctly identify patients with acute allergic reactions that require epinephrine administration.  

A new study identifies APOC1 and NOP16 as potential prostate cancer biomarkers that may improve early diagnosis and complement current PSA testing.

Most adolescents maintained stable mental health through the COVID-19 pandemic, despite widespread concerns about rising depression, according to a large US cohort study.

New trial analysis suggests fewer injections may safely maintain vision in patients with polypoidal choroidal vasculopathy.

Researchers have created a highly detailed spatial multiomic atlas to date of glioma tumour microenvironments.

New research shows resilience partially offsets financial toxicity and improves quality of life in patients with primary liver cancer, highlighting the importance of psychosocial support.

Sequential embolisation and renal cryoablation shows high efficacy and low severe adverse events in patients with renal masses over 3 cm.

Colonic stent placement as a bridge to surgery shows similar survival to emergency resection while reducing stoma rates in obstructive colorectal cancer.

New genetic evidence suggests that people with an inherited tendency towards blood clots may be at higher risk of developing long COVID.

Curcumin supplementation modestly lowers systolic blood pressure in adults with prediabetes and Type 2 diabetes.

Novel multistage malaria vaccine demonstrates over 50% efficacy following controlled human malaria infection, supporting further trials in children.

Research links PFAS mixtures and genetic susceptibility to increased odds of multiple sclerosis in a large Swedish study.

New trial analysis shows COPD treatment withdrawal, including LAMA and ICS discontinuation, can trigger early exacerbation risk.

By reconstructing a fetal liver–specific niche, FLOs enable simultaneous development of hepatic and hematopoietic lineages, revealing cross-talk essential for understanding human liver development and immune injury.

An inflatable device may reshape prone care by improving safety and efficiency in busy intensive care units.

RA patients positive for anti-EBV EA-DR IgG antibodies show higher ACPA levels and increased disease activity, suggesting a link between Epstein–Barr virus immune responses and rheumatoid arthritis.

Close relatives of azoospermic and oligozoospermic men showed the highest all-cause and cause-specific mortality risk, including deaths attributed to cardiovascular disease and congenital conditions.

New research shows combining biomarkers and genetics may dramatically improve heart disease risk assessment and prevention strategies.

Long term research links high fat cheese and cream consumption to lower dementia risk in older adults.

A combined ultrasound and CT model accurately predicts spontaneous stone passage in ureteral stones ≤10 mm, supporting safer conservative management decisions.

Sea saline nasal irrigation lowers bacterial colonisation and incidence of acute upper respiratory infections in children.

More than 386,000 people waited longer than six weeks for testing, accounting for around one in five patients on diagnostic waiting lists.

3D bioprinting enables realistic human skin models and may transform research into chronic inflammatory skin diseases.

Emerging evidence highlights psilocybin as a potential therapy for treatment-resistant OCD, while cannabinoids show limited efficacy.

A multi-species synbiotic supplement has led to measurable improvements in weight, metabolic control and cardiovascular risk markers in elderly people with type 2 diabetes.

High airway TSLP levels identify a subset of severe asthma patients with type 2 inflammation, mucus plugging, and airway remodelling despite corticosteroid treatment.

AI-enhanced ECG screening uncovers silent liver cirrhosis, enabling earlier diagnosis and intervention in routine primary care.

Large cohort study reveals elevated meningiomas risk decades after childhood cancer treatment.

ASAS-PerSpA study finds Japanese patients with axial psoriatic arthritis have lower disease activity and better function than other regions, with notable differences in treatment patterns.

This new resource aims to change that by providing a detailed framework for understanding how different cancers maintain their telomeres and where their weaknesses lie.

Left atrial appendage closure causes a short-term rise in atrial pressure, but no adverse changes in heart structure or biomarkers were seen during follow-up.

Being vaccinated against COVID-19 was associated with a lower risk of hospitalisation, severe maternal disease and preterm birth, regardless of the COVID-19 variant time period, the study found.

Baloxavir significantly reduces hospitalisations in influenza outpatients compared with oseltamivir, highlighting its value during flu season.

Survey study shows COVID-19-related behavioral changes led to delayed colorectal cancer diagnosis and more advanced disease, highlighting the importance of maintaining screening during health crises.

New epidemiological data reveal long serial intervals and sustained scabies transmission in Europe, highlighting how modest prevention could curb epidemic growth.

Nationwide data reveal increasing PCI use after TAVR with low complication rates and important planning implications.

A novel form of chest X-ray imaging could help clinicians detect pneumothorax more quickly and with greater confidence.

Robot-assisted radical prostatectomy was linked to significantly fewer short-term complications than open surgery in a large nationwide French cohort study.

The nSOFA score predicts prolonged mechanical ventilation in newborns with NRDS. Early risk stratification may improve NICU care and outcomes.

Large study tracks how intraventricular hemorrhage influences academic progress from primary school to adolescence.

Between 2011 and 2021, 7,322 men were diagnosed with germ cell cancer in Sweden and Norway.

New research suggests flavanol-rich foods, such as cocoa, may help protect blood vessel function during prolonged sitting.

Interview study shows injectable on-demand treatments for hereditary angioedema may delay care and negatively impact quality of life, highlighting demand for oral options.

A long-term study shows that recurrence beyond the Milan criteria, rather than recurrence itself, drives poorer survival after curative hepatocellular carcinoma resection.

A scoping review shows machine learning models may help predict response to biologic and targeted synthetic DMARDs in rheumatoid arthritis, though validation gaps remain.

Researchers have identified a molecular pathway that helps explain why certain subtypes of triple negative breast cancer are more likely to spread to bone.

The WHO releases 40 evidence-based recommendations and six good practice statements for preventing, diagnosing, and treating infertility.

A targeted physiotherapy approach has been shown to deliver sustained improvements in people with chronic disabling low back pain.

A randomized trial shows combined water exchange and cap-assisted colonoscopy shortens cecal intubation time and reduces pain in unsedated procedures.

High-throughput proteomics identifies inflammatory clusters and biomarkers associated with disease severity and treatment response in bullous pemphigoid.

A randomised trial shows transcutaneous tibial nerve stimulation reduces catheter-related bladder discomfort and improves early recovery after urologic surgery.

Study shows that exhaled volatile organic compounds, including propanoic and nonanoic acids, could be used as non-invasive biomarkers for asthma.

These findings indicate that the low-dose CT component of PET/CT, already performed as part of routine prostate cancer care, can reliably provide information relevant to bone health.

Researchers uncover combined energy, immune, and vascular disruptions that help explain the complex biology of ME/CFS.

Investigators describe this as the largest study to date linking thromboinflammation biomarkers with thrombosis risk in myeloproliferative neoplasms.

NHANES data show glycaemic status and macronutrient intake are linked to sleep duration, sleep disorders, and sleep quality.

A clinical trial shows immune-targeted therapy tailored to sepsis subtypes improves organ function by day 9, offering a new approach to treatment.

Study shows DAAs and interferon offer similar long-term protection against hepatocellular carcinoma after hepatitis C cure and introduces a nomogram to predict 8-year HCC risk.

Study reveals digital health literacy includes navigation, appraisal, and confidence, not just basic online skills.

Global meta-analysis highlights nutrient differences and growth patterns in vegetarian and vegan versus omnivorous diets.

Several widely used food preservatives have been linked to a higher risk of cancer according to a large French study.

WHO’s review of studies from 2010–2025 confirms vaccines, including thiomersal-containing ones, are not associated with autism.

A new study shows that grip strength cannot be used as a proxy for core muscle endurance in axial spondyloarthritis, highlighting the need for targeted core assessments.

A Pan-European study reports high rates of addictive behaviours among patients with chronic skin diseases, linked to poorer quality of life and key demographic factors.

Blood biomarker p-tau217 helps identify sleep disorder patients at highest risk of cognitive decline.

A nasal pressure technique significantly reduces pain during urinary catheterisation, offering a simple, non-pharmacological option for patient comfort in the ED.

New meta-analysis finds e-cigarette use may increase the risk of heart attack and stroke, even after adjusting for cigarette smoking.

This combined model achieved a high level of accuracy, suggesting that imaging data alongside basic clinical information could be effective for screening.

A UK trial explores immune suppression in early Parkinson’s disease with important lessons for future treatments.

Researchers analysed survey responses from more than 1,000 adults taking part in a large multisite trial of advance care planning.

High HbA1c variability is independently associated with poorer neurocognitive outcomes in children with type 1 diabetes.

Very low-dose multi-nut oral immunotherapy significantly increased tolerance in children with multiple nut allergies, with a favourable safety profile and no epinephrine use.

Phase II ELMWOOD trial shows elafibranor is well tolerated and improves liver biochemistry and pruritus in primary sclerosing cholangitis, supporting further trials.

A clinical trial shows home gamma stimulation may safely improve cognitive outcomes in people with early Alzheimer’s disease.

A six-year cohort study shows low muscle strength, not sarcopenia, is linked to increased falls risk in patients with rheumatoid arthritis, highlighting the importance of functional assessments.

New research shows how catheter based debanding may change care after pulmonary artery banding in infants.

Inflammatory molecules circulating in the blood may worsen disease symptoms and points to new opportunities for targeted therapy.

New Global Burden of Disease 2023 data show lower respiratory infections still cause 2.5 million deaths yearly, with children and older adults most affected.

A retrospective cohort study shows that gastrointestinal involvement in granulomatosis with polyangiitis is linked to higher disease activity, earlier relapse, and a threefold increase in mortality risk.

Most systemic therapy-naïve patients with moderate-to-severe atopic dermatitis or psoriasis in Germany wish to escalate treatment, with clear preferences for administration route.

AI analysis of EEG scans helps distinguish frontotemporal dementia from Alzheimer’s disease with high accuracy.

A large NHANES analysis shows the red cell distribution width-to-albumin ratio is strongly associated with diabetic kidney disease risk in adults with diabetes.

Chronic bronchitis affects nearly 10% of adults in low- and middle-income countries, with links to worse respiratory outcomes.

A study has found that the way medical images are prepared before analysis can have a significant impact on the performance of deep learning models.

Find out more about early evidence supporting biomarker-guided cardioprotection in patients receiving anthracycline therapy.

Researchers have developed a genomic model that could improve predictions of long-term recurrence in a common form of breast cancer.

A highly accurate AI model improves prediabetes prediction by integrating antioxidant status with standard risk factors.

A randomized controlled trial shows that the TNF inhibitor etanercept improves cerebral blood flow, vascular reactivity, and endothelial function in elderly patients with rheumatoid arthritis.

A phase 2 trial finds tinengotinib demonstrates anti-tumour activity in previously treated advanced cholangiocarcinoma with FGFR alterations.

Review paper concludes that stem cells and growth factors are effective in treating diabetic foot ulcers. But improved treatment protocols are needed before wider clinical adoption.

Discover how magnesium supplements showed no measurable arrhythmia benefit in a major ICU study using causal methods.

Critically ill patients with systemic lupus erythematosus show reduced ICU survival, driven largely by renal dysfunction, with glucocorticoids potentially mitigating mortality risk.

A 3-year study in Israel shows pooled-saliva cCMV universal screening identifies hidden infections in newborns, enabling early treatment and improving outcomes.

A large, multiethnic study reveals distinct facial microbiota patterns in adolescents with acne, identifying key bacterial species linked to acne pathology.

A major cohort study finds that inadequate vitamin D in pregnancy may raise the risk of early dental caries in children.

Doctors may not need to avoid steroids before biopsy in patients with a common aggressive lymphoma, according to a new study.

CT imaging features including appendicolith, appendiceal diameter, fat stranding, and periappendiceal air help identify patients at risk of complicated acute appendicitis.

New research suggests routine blood-based inflammation markers could help predict which men with enlarged prostates are likely to develop more severe symptoms.

A large USA study finds social media use is linked to increasing inattention symptoms in school-aged children over 4 years.

A study reveals how nicotine withdrawal increases pain and opioid use after surgery by altering brain activity.

The UKHSA has detected an inter-clade recombinant mpox virus in England; vaccines remain effective and risk to the public is low.

A new multinational study reports that rifaximin use in cirrhosis and hepatic encephalopathy is linked to significantly higher risks of antimicrobial resistance and severe infections.

A major study examines ten-year heart changes in marathon runners, revealing reassuring findings for recreational endurance athletes.

Real-world data show switching to IL-17 inhibitors after TNF inhibitor failure improves treatment retention compared with TNF cycling in psoriatic arthritis.

A major international trial reports no difference in outcomes when using higher vs lower initial oxygen levels for preterm resuscitation in extremely preterm infants.

New intranasal BPZE1 vaccine is safe and reduces Bordetella pertussis colonisation, offering hope for whooping cough prevention.

A new Nordic study reports no clear increase in major congenital malformations among infants exposed to topical retinoids in early pregnancy.

Researchers report that yoga and general exercise deliver similar sleep outcomes for women managing urinary incontinence.

New research identifies a specific monocyte gene signature that predicts mortality in IPF, offering potential targets precision medicine.

A major study shows how heat exposure affects early development across six countries. Find out what researchers discovered.

Novel oral GRK2-biased β2 adrenergic receptor agonists show potential for safer glucose management and obesity treatment.

Large PBC cohort shows current liver stiffness measurement >10 kPa predicts hepatic decompensation, outperforming biochemical response or LSM trajectory.

A study demonstrates how AI transforms bionic hand function, improving precision and reducing effort for amputees.

A hybrid AI-human scoring system delivers expert-level accuracy in ulcerative colitis endoscopic assessment while reducing human review by 81 percent.

Meta-analysis finds sperm retrieval success in nonmosaic Klinefelter syndrome similar in adolescents and adults, with possible decline only after age 40.

Women with eczema or other atopic skin conditions may face greater risks of implant-related problems after breast reconstruction, according to a new study led by researchers in Texas.

A large study of 1,100 adults shows how nasal microbiome structure influences Staphylococcus aureus carriage.

New research shows metabolic liver disease is linked to increased androgenetic alopecia risk, with stronger effects in women and those with unhealthy lifestyle patterns.

A new rapid, low-cost sequencing method delivers four-hour UTI diagnosis with high accuracy, detecting pathogens missed by routine tests and improving antibiotic decision-making.

Gas stoves are a major source of indoor nitrogen dioxide, raising exposure levels WHO guidelines for millions of people.

Retrospective study in 755 children shows how a deep-learning algorithm can support clinicians correctly diagnose paediatric elbow fractures, although further developments are required.

A major study links PTSD to faster brain ageing in WTC responders. Find out what the data shows.

Researchers emphasize that these results, together with previous evidence, point to a growing need for stricter controls on synthetic phenols.

A new ANAcare pathway offers clinicians practical, harmonised steps to apply the latest guidelines for diagnosing IgE-mediated food allergy.

New research confirms the GOLDEN model reliably predicts HBsAg loss in interferon-treated chronic hepatitis B patients, supporting more personalized treatment strategies.

Severe sleep loss in pregnant mice depletes daughters’ ovarian germ cells via ferroptosis, partly reversible with a ferroptosis inhibitor, raising concerns for future fertility.

The findings provide reassurance amid growing global use of drugs such as semaglutide and tirzepatide.

The WHO World Malaria Report 2025 highlights gains in malaria control, ongoing challenges in Africa, and lifesaving interventions.

Fibroblasts fuel skin and systemic inflammation via a CXCL10–glycolysis axis in dermatomyositis, offering new metabolic treatment opportunities.

Early weight management in childhood significantly reduces the risk of developing coronary heart disease later in life.

Escalating antimicrobial resistance has been identified among urology inpatients in a new study from a Turkish tertiary centre, highlighting urgent stewardship needs.

New data show that 28% of UK GPs are using AI tools to streamline admin tasks, reduce burnout, and improve patient care.

New research reveals surprising strengths linked to mental illness, from creativity to resilience and improved long term wellbeing.

Researchers have developed a new strategy that allows engineered T cells to recognize and respond to a single tumour antigen through two coordinated mechanisms.

A prospective study finds that using both diffusion-weighted MRI and spectral Doppler ultrasound significantly improves classification of benign and malignant salivary gland tumours.

A new US Drug Allergy Registry report outlines standardised paediatric antibiotic allergy testing protocols to curb unnecessary labels and harmonise research.

Bioinformatics work identifies FAM72A–D as powerful prognostic markers in liver cancer and unveils a compact FAM72 risk score that outperforms existing gene models.

New review highlights major advances in HIV and STI prevention, diagnostics, and integrated service delivery, urging a unified approach to meet 2030 global goals.

Learn how a pilot trial shows low-frequency electrical stimulation with exercise enhances local bone outcomes in premenopausal women.

Discover how the brain’s structural networks evolve in five distinct phases across the human lifespan, from childhood to late ageing.

A phase 3 trial shows dupilumab significantly improves quality of life in omalizumab-naïve patients with chronic spontaneous urticaria.

Combining glecirasib and sitneprotafib shows encouraging efficacy and safety in patients with KRAS G12C-mutated NSCLC.

Scientists used a chemotherapy-free stem cell approach to reverse type 1 diabetes in mice, restoring insulin production and immune balance without long-term medication.

A new BSI-CIPN report warns that UK clinical immunology and allergy services are critically understaffed, calling for urgent national workforce planning and investment.

Silencing S100A11 protects against steatosis, inflammation and fibrosis in murine MASH, uncovering HK2 as a key metabolic driver and potential therapeutic target.

A large Norwegian study shows that higher cardiorespiratory fitness is linked to a significantly lower long-term risk of urinary tract, bladder, and kidney cancers.

Blood based dementia biomarkers reveal which patients with memory concerns are most likely to worsen.

A new review highlights kefir-derived peptides, probiotics and kefiran as promising natural strategies for bone health and osteoporosis prevention.

A world-first personalised CRISPR base-editing therapy has shown promising early results in an infant with CPS1 deficiency, demonstrating the potential of rapid, bespoke gene-editing treatments for ultra-rare genetic diseases.

Garsorasib shrank tumours in nearly half of patients with KRAS G12C pancreatic cancer and showed manageable side effects.

IMCAS World Congress 2026 unites global dermatology experts to explore advances in science, aesthetics, and complication management across lasers, dermatology, and injectables.

New phase 3 trial finds ivarmacitinib ointment provides rapid, lasting relief from mild-to-moderate eczema with a favourable safety profile.

New research shows a quick neck ultrasound may identify older men at increased risk of heart failure.

A new study highlights oxidative and neuroimmune changes in diabetic urinary incontinence, identifying 4-HNE as a key biomarker differentiating diabetic and non-diabetic cases.

PS-OCT reveals distinct scleral fibre changes in pathologic myopia, offering new clues to prevent vision loss.

Experts call for consistent, specialist care throughout life to prevent complications and improve outcomes for people with sickle cell disease.

A rare case of ABPA presenting as pyopneumothorax highlights the need for early recognition of pleural complications in asthmatic patients.

High-dose aluminum adjuvant Imject Alum induces immune-mediated liver inflammation and fibrosis in mice, offering a new preclinical model that mirrors human cirrhosis biology.

BSR has published an updated guideline on the safe use of csDMARDs, introducing new evidence, paediatric guidance, and risk-adaptive monitoring across the full life course.

Engineered herpes virus targets glioblastoma cells, destroying tumours while activating immune defences in preclinical brain cancer models.

New test shows high sensitivity for tuberculosis, providing a faster, near-point-of-care option for early detection and prevention.

Early-stage primary biliary cholangitis shows distinct blood lipid changes tied to inflammation and fibrosis, offering clues to disease activity and potential new biomarkers.

A large retrospective study shows JAK2 gene fusion occurs in both aggressive and indolent cutaneous T-cell lymphomas, offering new insight into diagnosis and targeted treatment.

An automated MRI decision aid (ProAI) improves detection of clinically significant prostate cancer, boosting accuracy and cutting radiology workload by 32%.

Over half of patients with severe asthma discontinued oral corticosteroids while maintaining disease control, major study finds.

Phase 1 trial shows single-fraction stereotactic breast irradiation is safe and effective

A prospective multicenter study shows an MRI-based AI tool can accurately distinguish PD, MSA and PSP, with results confirmed by neuropathology.

Gold-standard clamp trial shows metformin fails to improve insulin resistance in type 1 diabetes, highlighting unmet treatment needs.

AI missed nearly one-third of breast cancer cases in a new study, but diffusion-weighted MRI detected most of these overlooked tumours, especially in dense breast tissue.

NHS England has issued a national alert after penicillin allergies were mistakenly recorded as penicillamine allergies, putting patients at risk of severe anaphylaxis.