Psoriasis is a chronic, inflammatory skin disease with a high prevalence in the general population. However, though psoriasis may involve all sites of the body, it most frequently involves the genitals. Psoriasis involvement of the genital region can be uncomfortable and embarrassing for both men and women. The psoriatic lesions can cause pain, itching, and burning sensation, furthermore it can determine a significant psychological impact. Patients with recurrent genital lesions experience significantly worse quality of life, sexual dysfunction, and distress. In addition, genital psoriasis (GP) can be difficult to treat, due to the sensitivity of genital skin, and few studies have been published on this topic. This paper aims to summarise the studies reported in the literature, designed to evaluate the efficacy and tolerability of topical tacrolimus on GP. Moreover, we report the cases of two patients presenting with GP who have been treated with tacrolimus.
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