Allergy & Immunology

These findings suggest that most children can maintain tolerance to nuts even after a short period without exposure, following a structured course of N-OIT.

Conducted across 19 countries, this large-scale observational study gathered data from 1,392 patients with CSU and 1,374 healthy controls.

This study investigates the role of the intranasal Schirmer test as a supportive or alternative tool to anterior rhinomanometry for allergic rhinitis.

Discover a study that highlights the importance of identifying high-risk children through biomarkers and better understanding neutrophil function in RSV infection.

Moreover, the infant’s gut microbiota may play a role in both allergy development and tolerance.

Interestingly, the study also revealed a disconnect between clinical and biological remission.

The study highlights a potentially critical role for the BDNF-NTRK2 pathway in symptom development.

This study is especially important because existing diagnostic methods, including skin testing, have shown limited sensitivity.

The PHECDA trial evaluated stapokibart as an add-on therapy during pollen season in adults with moderate-to-severe seasonal allergic rhinitis.

Discover a study that found that 58.8% of shrimp-allergic patients also had allergic rhinitis, and 11.7% had asthma. Learn more.

Children with septic shock who received ulinastatin alongside standard therapy showed significantly improved clinical outcomes.

Excessive anxiety surrounding food allergies is common and can significantly impact a patient’s quality of life.

A novel CAR T cell therapy has shown encouraging results in children and adults with relapsed/refractory B-cell acute lymphoblastic leukaemia.

Each year, up to 138,000 people die and around 400,000 more are left permanently disabled from snakebites.

Researchers have explored the potential of intense pulsed light therapy as a supplementary treatment for refractory SAC.

The analysis demonstrated significant reductions in HAE attacks among adolescent patients.

Researchers developed a new evolutionary framework centred on immune robustness, the ability to fight infection while limiting damage.

A recent randomised clinical trial sought to determine whether high-dose aspirin remains necessary during acute-stage KD treatment.

The RILECSU phase 2 clinical trial has introduced a potential new option: rilzabrutinib.

During the immunosuppressive phase, researchers identified a marked decline in monocyte function and maturation.

Researchers have discovered a myeloid-derived APC population that is essential for generating both food- and microbiota-specific peripherally induced regulatory T cells.

The study suggests that initiating Artemisia annua SLIT during the pollen season is just as safe and well-tolerated as starting it before.

The results suggest that Wendan Decoction and acupuncture into treatment plans may enhance clinical outcomes for patients with urticaria.

A recent single-blind, randomised controlled trial evaluated the efficacy of normal saline nasal irrigation in managing allergic rhinitis symptoms.

The study found gluten-derived excipients in 44.4% of analgesics and antipyretics.

Over half of the studies identified a direct link between climate change and extended pollen seasons.

The revised mRNA-1010 formulation, evaluated in a subsequent trial, met all primary immunogenicity goals.

The study suggests that chronic inflammation caused by allergic rhinitis could contribute to carcinogenesis through oxidative stress.

Mental health concerns were prevalent, with nearly all families experiencing stress.

This study aimed to assess whether maternal exposure to LC-PCBs in indoor air during pregnancy was associated with the development of asthma.

The study also highlighted a reduction in restricted antibiotic use among patients in the intervention group compared with the control group.

This study explored the hypothesis that mucus transpiration contributes to airway inflammation and chronic respiratory disease.

While food additives play a crucial role in food preservation and enhancement, their potential long-term effects on immune and metabolic health remain a growing concern.

Recent research has identified microRNAs as crucial regulators of inflammation, offering potential new insights into allergic rhinitis pathogenesis.

Beyond antibody transfer through the placenta, breastfeeding may further enhance infant protection.

Discover why new research suggests that early and consistent exposure to food allergens may influence the development of tolerance.

Rocatinlimab, a novel therapy targeting the OX40 pathway, shows potential as an alternative treatment.

Current treatments focus on managing symptoms and include moisturisers, corticosteroids, and calcineurin inhibitors.

Recent studies demonstrate that IL-5 treatment substantially increases type I and III IFN production in mast cells exposed to respiratory viruses.

The Clinical Support Tool is a significant advancement, integrating clear clinical criteria and epinephrine treatment guidelines.

Given that 60% of asthma-related costs are attributed to severe, uncontrolled cases, the need for cost-effective treatment alternatives is crucial.

These findings indicate that omalizumab is a more effective and safer option than multi-allergen OIT for treating multi-food allergy.

Fine dust, a notable seasonal allergen, exacerbates allergic rhinitis symptoms and contributes to respiratory diseases.

Peanut oral immunotherapy using home-measured peanut butter significantly improves long-term desensitisation in children with high-threshold peanut allergy.

A proof-of-concept study was conducted to explore whether dupilumab could induce desensitisation to peanut in children with peanut allergy.

These findings suggest that vonoprazan and tetracycline dual therapy is both effective and well-tolerated, offering a valuable alternative.

These findings suggest that a preoperative radiation therapy boost can safely induce a short-term increase in stromal tumour-infiltrating lymphocytes.

The ability to pharmacologically degrade fat mass and obesity-associated protein represents a promising avenue for enhancing anti-tumour immunity.