Oncology

Solid nodules, smoking, and male sex are linked to fast-growing lung cancers on CT, highlighting patients at higher risk of rapid progression.

Scientists have discovered a small molecule inhibitor that impedes the growth of triple-negative breast cancer by inhibiting enolase 1.

Up to four in 10 cancers worldwide could be prevented, a new analysis from WHO and its International Agency for Research on Cancer has revealed.

Over a total number of 105,934 participants, interval cancer rates were 1.55 (95% CI: 1·23–1·92) and 1.76 (95% CI: 1·42–2·15) per 1000 participants in the intervention and control group respectively.

Occupational therapy interventions mitigate chemotherapy-induced cognitive impairment in women with breast cancer, showing positive trends in improving cognitive function.

Vegetarian diets are associated with a lower risk of multiple cancers, according to the largest study to date in this field.

GLP-1 receptor agonists were not associated with recurrence or progression in well differentiated thyroid cancer, supporting safe clinical use.

A temperature tested photonic crystal sensor achieves over 91% accuracy in cervical cancer screening using label free optical detection.

A new water jet surgical device combines cutting and anaesthesia, reducing tissue injury and allowing precise drug delivery.

Metastatic ILC shows significant biomarker heterogeneity, limiting single biopsy reliability and highlighting challenges in detection and monitoring.

Breast cancer survivors with high genetic risk for excess body weight had 15% higher mortality, and required more weekly walking to mitigate inherited risk.

Phase two data show Elenagen combined with gemcitabine significantly prolongs overall survival in platinum resistant ovarian cancer without added safety concerns.

A Phase three trial shows early immunochemotherapy significantly improves survival and enhances CD8 T cell responses in advanced non small cell lung cancer.

Large cohort study shows GLP-1 receptor agonists combined with progestins lower endometrial cancer risk and reduce hysterectomy incidence in women with benign uterine disease.

Phase 2 findings show neoadjuvant pembrolizumab produced a 71% pathological complete response rate in resectable desmoplastic melanoma, with favourable safety and three year follow up outcomes.

A large US registry study found significantly worse one year cancer survival during 2020 and 2021, with an estimated 17 390 excess deaths linked to COVID-19 pandemic disruptions in care.

Quantitative digital pathology revealed distinct morphometric features among mixed odontogenic tumors, suggesting virtual cell analysis may aid diagnosis when conventional histology is inconclusive.

Epigenetic therapy combined with immunotherapy reshaped the tumour microenvironment in platinum-resistant ovarian cancer, promoting inflammatory immune signalling and disease control in half of treated patients.

A new artificial intelligence system significantly improves MRI-based breast cancer diagnosis, reducing false-positive rates and inter-reader variability while enhancing risk stratification of BI-RADS 4 lesions.

Elevated copper levels in tumour tissues, along with lymph node status and TNM stage, emerged as important discriminators of disease characteristics, highlighting potential links between metal imbalances and CRC progression. 

A comparative study shows that lightweight convolutional neural networks can accurately classify lung cancer histopathology with strong generalisation and reduced computational complexity.

Deep learning integration of FDG PET-CT and clinical data significantly improves survival prediction in non-metastatic breast cancer, offering a transparent and more precise approach to prognostic stratification.

Sarcopenia, myosteatosis, and systemic immune inflammatory index were independently associated with reduced oesophageal cancer survival in patients treated with immunotherapy, supporting their role in prognostic assessment.

A large English registry analysis shows survival in multiple myeloma declines with each treatment line and is significantly longer in patients receiving autologous stem cell transplant.

Machine learning models accurately predict survival after surgery for upper tract urothelial cancer, supporting personalised follow up and adjuvant treatment decisions.

Low baseline ctDNA and early clearance during treatment are strongly associated with improved response and survival in advanced breast cancer, highlighting ctDNA as a promising predictive and surrogate biomarker.

New data show that deep-learning classifiers can accurately identify key driver alterations in non-small cell lung cancer…

Key cell cycle genes have been identified as prognostic biomarkers in nasopharyngeal carcinoma, enabling a new prediction model that integrates gene expression with clinical factors to improve survival estimation.

Baseline fatigue reported at treatment initiation is associated with a significantly increased risk of severe, life threatening, and fatal cancer treatment related toxic effects.

Perioperative nivolumab significantly improved survival and pathological response in stage III non-small-cell lung cancer, challenging the traditionally poor prognosis associated with N2 nodal disease.

Using large public datasets including TCGA, GEO and GTEx, researchers found that BAZ2B expression was consistently reduced in several cancer types, with particularly marked downregulation in breast cancer.

AI system surpasses radiologists in detecting pancreatic cancer on CT scans, promising earlier diagnosis and better outcomes.

Prostate cancer remains the most common cancer in men in the UK, with around 55,000 new cases and 12,000 deaths each year and is currently the most common cancer without a national screening programme.

Researchers have identified chromosomal instability in circulating tumour cells as a prognostic and predictive biomarker in metastatic castration resistant prostate cancer.

The incidence of early-onset colorectal cancer has been increasing worldwide, a trend that has coincided with growing intake of ultraprocessed foods.

Access to blood transfusions emerged as the most highly valued service, with a mean standardised importance score of 20.53.

Researchers have developed a new prediction tool that could help clinicians better assess whether complete tumour removal is achievable in women with advanced epithelial ovarian cancer.

Researchers have created a highly detailed spatial multiomic atlas to date of glioma tumour microenvironments.

This new resource aims to change that by providing a detailed framework for understanding how different cancers maintain their telomeres and where their weaknesses lie.

Between 2011 and 2021, 7,322 men were diagnosed with germ cell cancer in Sweden and Norway.

Researchers have identified a molecular pathway that helps explain why certain subtypes of triple negative breast cancer are more likely to spread to bone.

Several widely used food preservatives have been linked to a higher risk of cancer according to a large French study.

Researchers analysed survey responses from more than 1,000 adults taking part in a large multisite trial of advance care planning.

Researchers have developed a genomic model that could improve predictions of long-term recurrence in a common form of breast cancer.

Women with eczema or other atopic skin conditions may face greater risks of implant-related problems after breast reconstruction, according to a new study led by researchers in Texas.

The findings provide reassurance amid growing global use of drugs such as semaglutide and tirzepatide.

Researchers have developed a new strategy that allows engineered T cells to recognize and respond to a single tumour antigen through two coordinated mechanisms.

Garsorasib shrank tumours in nearly half of patients with KRAS G12C pancreatic cancer and showed manageable side effects.

Engineered herpes virus targets glioblastoma cells, destroying tumours while activating immune defences in preclinical brain cancer models.

Phase 1 trial shows single-fraction stereotactic breast irradiation is safe and effective

Genomic profiling revealed druggable targets in 39% of advanced prostate cancer cases, guiding personalised treatments.

A targeted screening programme improved early skin cancer detection in transplant recipients without increasing healthcare demands.

Tamoxifen treatment may reduce the effectiveness of scalp cooling, leading to persistent hair loss after chemotherapy.

DenseWolf-K, a hybrid AI framework, achieved 99.64% accuracy in brain tumour MRI classification, revolutionising medical imaging.

Nivolumab shows lasting melanoma recurrence prevention, with long-term safety, in largest-ever CheckMate 238 trial analysis.

A new study has identified TRIM56, an E3 ubiquitin ligase, as a key activator of the proto-oncogene Src in hepatocellular carcinoma.

A new study has found that it is older age hat is most strongly linked to poorer survival outcomes in liver cancer.

Sacituzumab tirumotecan improves survival over platinum chemotherapy in EGFR‑mutated NSCLC, OptiTROP‑Lung04 finds.

Early clinical results reveal that the novel KRAS G12D inhibitor GFH375 achieves a 41% response rate and 97% disease control in advanced…

The DESTINY-Breast11 phase 3 trial presented at ESMO 2025 revealed that the anthracycline-free neoadjuvant T-DXd-THP regimen achieved a 67.3% pathologic complete response rate.

A risk-stratified approach significantly enhanced skin cancer detection after organ transplantation without increasing health care burden.

Statin use linked to better survival but higher cardiac adverse events in advanced prostate cancer patients treated with apalutamide, according to recent analysis.

Study reveals how TP53 mutations alter lung adenocarcinoma tumour microenvironment, influencing progression and immunotherapy response.

New study reveals how iron levels influence FLASH radiotherapy’s dual effect of tumour control and normal tissue protection.

A longitudinal study of 188 cervical cancer patients undergoing brachytherapy revealed that multidimensional fatigue slightly increased during treatment, peaking after five sessions, then significantly decreased one month post-treatment.

A new study reveals circulating tumour DNA correlates with tumour volume in metastatic pancreatic cancer, particularly with liver metastases.

Oral bacteria and fungi have been identified as risk factors for the development of pancreatic cancer, making them potential non-invasive biomarkers for identifying individuals at high risk.

Researchers have uncovered a central role for Tropomodulin-2 (TMOD2) in promoting colorectal cancer (CRC) progression and liver metastasis.

Researchers are making progress in the fight against neuroblastoma (NB), a challenging childhood tumour known for its resistance to chemotherapy.

A groundbreaking new tool, Ovatools, is set to transform ovarian cancer diagnosis in UK primary care by providing personalised risk scores that combine CA125 blood test results with a patient’s age.

A recent study introduces an advanced ex vivo 3D micro-tumour testing platform that accurately forecasts individual patient response to chemotherapy, potentially revolutionizing personalized treatment decisions.

Minimal residual disease (MRD) is a major barrier to curing advanced ovarian cancer, even in patients who appear disease-free after initial therapy. A recent study of 95 patients showed that MRD detected through second-look laparoscopy or circulating tumor DNA strongly predicted shorter progression-free and overall survival.

A proteome-wide genetic study found that the protein FSHB is strongly associated with increased risk of endometrioid ovarian cancer.

Childhood cancer survivors who are obese and less physically active face a significantly higher risk of developing subsequent cancers later in life, according to new research….

A groundbreaking AI model, trained on over 1.3 million MRI–pathology pairs, is redefining prostate cancer diagnosis. The MRI‑PTPCa system delivers near‑perfect accuracy in grading tumors, offering a safe, noninvasive alternative to biopsies while improving clinical decision‑making and patient outcomes.

Survivors of childhood cancer who live past age 50 face a significantly higher risk of premature death and serious health problems compared with the general population…

A new study has revealed how subtle oxidative modifications of proteins fine-tune cell division and determine how cells respond to stress. Read on to learn more!

Lower vitamin D levels linked to higher thyroid cancer risk, new meta-analysis suggests clinical importance.

A four-year prospective study finds that breast cancer survivors experience improvements in depression, anxiety, pain, and quality of life after treatment, though women who underwent mastectomy reported higher long-term anxiety than those who had breast-conserving surgery.

A promising new study has identified a highly accurate, non-invasive method to diagnose non-small cell lung cancer (NSCLC) using a blood test based on tRNA signatures.

Researchers analyzed over 6,500 treatment episodes between January 2017 and December 2020, with follow-up through June 2024

A new bispecific antibody therapy, AFM28, has shown strong preclinical results in targeting treatment-resistant cells in acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS), according to new research.

A new review highlights the growing role of fibroblast growth factor receptor 2 isoform IIIb (FGFR2b) protein in gastric and gastroesophageal junction (G/GEJ) adenocarcinomas.  

A new AI model, AAnet, reveals that tumours are made up of a continuum of functional cell states. It identifies GLUT3 as a key driver of metastasis.

A new study from Ireland shows that neoadjuvant chemoradiation is safe and effective in older adults with oesophageal cancer, with no survival disadvantage versus younger patients.

Researchers in Germany have developed HANCOCK, a comprehensive dataset of head and neck cancer cases, to support biomarker discovery and precision oncology.

At least 60% of liver cancer diagnoses are linked to modifiable risk factors and could be prevented through global interventions

Higher levels of two cardiac biomarkers at baseline are associated with an increased risk of future cancer…

A new study has found that patients with metastatic non–small cell lung cancer and pre-existing rheumatoid arthritis have similar overall survival to those without RA when treated with immune checkpoint inhibitors…

Scientists have identified a rare and previously overlooked type of circulating tumour cell (CTC) in patients with metastatic breast cancer…

A new study has found that people living with HIV (PWH) in the United States are less likely to receive cancer treatment if they live in areas with lower income or educational attainment.

A new study has found that delaying surgery after a breast cancer diagnosis significantly increases the risk of breast cancer-specific mortality (BCSM), particularly for certain subtypes.

A new study suggests that shorter breastfeeding duration may significantly contribute to higher rates of triple negative breast cancer (TNBC) among Black women compared to their White counterparts.

A new study uncovers how melanomas can arise from minimal genetic changes, shedding light on the early, often elusive steps in skin cancer progression

A new clinical trial offers insight into tackling one of the biggest challenges in soft tissue sarcomas….

Despite alcohol being a leading preventable cause of cancer in the United States, public awareness of its cancer risk remains strikingly low, according to a new study.

A recent study identifies the Gαi3 protein as a key factor in bladder cancer progression. Researchers found that Gαi3 promotes tumour growth and survival by activating the Akt-mTOR pathway.

Researchers have developed an AI system that significantly increases detection of thoracic aortic aneurysms during routine breast MRIs.

Researchers have developed an AI-based multimodal fusion system that combines CT imaging and clinical data to predict survival in patients with unresectable hepatocellular carcinoma.

Research shows patients over 70 experience more complications and a higher death rate following rectal cancer surgery compared to younger patients.

A new study of nearly 129,000 adults has revealed that common midlife comorbidities, such as respiratory and cardiovascular conditions, are associated with an increased risk of cancer and cancer-related death.

A recent multi-centre study reveals taxane-based chemotherapy is linked to markedly better one-year survival in advanced triple-negative breast cancer with genomic instability, compared to platinum-based treatments.

A new study has projected that radiation exposure from computed tomography (CT) scans in the United States will result in approximately 103,000 future cancers.

New research presented at ESMO Breast 2025 reveals that certain gut bacteria and microbial functions are more common in breast cancer patients who later experience recurrence, highlighting the potential of the gut microbiome as a biomarker for relapse risk.

New research presented at ESMO Breast 2025 shows that alcohol consumption raises the risk of developing breast cancer, particularly hormone receptor-positive types, but does not appear to worsen survival or recurrence in those already diagnosed.

New data from ESMO Breast 2025 indicate that inherited DNA repair mutations could affect the effectiveness of CDK4/6 inhibitors in treating advanced breast cancer, with mutation carriers showing lower response rates and shorter survival trends.

New data presented at ESMO Breast 2025 show that short-course radiotherapy offers similar survival outcomes to conventional treatment following surgery and nodal irradiation for breast cancer.

Research shows that regular physical activity can help close the survival gap for stage III colon cancer, with those who exercise achieving survival rates similar to the general population.

Whole genome and transcriptome sequencing (WGTS) outperforms standard gene panels in diagnosing cancer of unknown origin, offering clearer tissue-of-origin insights and broader treatment options, according to new research.

A new study of 18,932 metastatic colorectal cancer patients reveals that microsatellite instability, albumin levels, and antibiotic use significantly impact survival rates when treated with immune checkpoint inhibitors, offering insights for personalised treatment.

A new genomic study has revealed diverse and treatment-influenced mutational patterns in tumours associated with Constitutional Mismatch Repair Deficiency …

A study involving 138 cancer patients found that a personalised lighting intervention, guided by wearable-tracked circadian rhythms, reduced fatigue and improved sleep, anxiety, and physical function.

A study from Hubei Cancer Hospital has found that breast cancer patients undergoing nipple-sparing mastectomy report significantly higher satisfaction with their breast appearance and sexual well-being than those who had skin-sparing mastectomy.

New research highlights the benefits of using Mixed Reality (MR) technology during right hemicolectomy for colon cancer.

New research from the Dutch Melanoma Treatment Registry shows that rechallenging advanced melanoma patients with the immunotherapy combo ipilimumab and nivolumab may offer renewed treatment benefits.

People who develop hypoparathyroidism after thyroid cancer surgery may face a significantly higher risk of several long-term health complications…

A recent study has found that six months of supervised resistance and aerobic exercise significantly improves sexual function in men with prostate cancer, while brief psychosexual education provides no additional benefits.

A new global study analyzing data from 1990 to 2021 uncovers significant regional disparities in female cancer burden. It highlights how risk factors like high BMI, poor diet, and unsafe sex drive the incidence of breast, cervical, and uterine cancers differently across socio-demographic levels.

A study shows that dentists can help identify early signs of childhood leukaemia through clinical and radiographical indicators, offering the potential for quicker diagnosis and improved outcomes.

A study reveals racial disparities in immunotherapy use for triple-negative breast cancer, with Black patients less likely to receive treatment.