Rheumatology - European Medical Journal

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29 Jul 2019

Efficacy and Safety of E6011, an Anti-Fractalkine Monoclonal Antibody, in MTX-IR Patients with Rheumatoid Arthritis

Fractalkine (CX3CL1, designated as FKN hereafter) is the sole member of the CX3C chemokine family which leads to dual actions, chemotaxis, and cell…
2 Mins
29 Jul 2019

Comparative Effectiveness Research in Observational Settings: Evaluating Two New Methods to Analyse Response Rates

Observational studies are being used more frequently to compare drug effectiveness. Authors typically report the proportion of patients…
2 Mins
29 Jul 2019

Circulating T Cell Clones in Preclinical Phases of Rheumatoid Arthritis

The aetiopathogenesis of rheumatoid arthritis (RA) is only partially understood, but is believed to result from a multi-step process, whereby…
1 Mins
29 Jul 2019

Comparison of PAXgene and Tempus Whole Blood RNA Collection and Isolation Systems for the Quantification of Type I Interferon-Stimulated Gene Expression

Type I IFN have important roles in many paediatric and adult rheumatic diseases and are a new therapeutic target for which several anti-IFN treatments…
1 Mins
29 Jul 2019

Effects of Successive Switches to Different Biosimilars Infliximab on Immunogenicity in Chronic Inflammatory Diseases in Daily Clinical Practice

Immunogenicity constitutes an important concern since it is associated with lower clinical responses and more adverse events…
1 Mins
31 Jul 2018

Treating Rheumatoid Arthritis to Target: Is Low Disease Activity Good Enough?

Treat-to-target principles in rheumatoid arthritis (RA) are now widely recognised as effective in achieving optimal disease outcomes. This study examined…
2 Mins
31 Jul 2018

Physician Global Assessments for Disease Activity in Rheumatoid Arthritis Are All Over the Map!

There have been many studies about patient global assessments of disease activity in rheumatoid arthritis (RA) and how these differ from physician global…
1 Mins
31 Jul 2018

Linking Systemic Angiogenic Markers to Synovial Vascularisation in Rheumatoid Arthritis

The synovium is the primary site of the rheumatoid arthritis (RA)-related inflammatory process. One of the most noticeable signs of synovitis is the…
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