Neurology

articles

July 2020

Editor's Pick: Current Paradigms to Explore the Gut Microbiota Linkage to Neurological Disorders

20 Mins

The human body harbours a diverse community of symbiotic, commensal, and pathogenic micro-organisms including bacteria, viruses, and fungi…

15 Mins

Dec

Clinical Profile and Outcome of Children with Acute Central Nervous System Infection in Kerala, India

Infection of the central nervous system is a significant cause of morbidity and mortality in children.

EMJ Neurology 8 [Supplement 2] 2020 Feature Image

14 Mins

Dec

The Role of Sphingosine 1-Phosphate Receptor Modulators in the Treatment of Multiple Sclerosis

Neurologists are familiar with S1P receptor modulators as a class, largely based on several years’ experience with fingolimod. Siponimod and ozanimod…

18 Mins

Nov

Empowering Physicians to Advance the Future of Alzheimer’s Disease Management and Care

Lack of or delayed diagnosis represents a substantial unmet need in AD. In Europe, around one-half of all cases are estimated to be without a formal…

7 Mins

Jul

Interview: Professor Michael Barnes

I became interested whilst working in multiple sclerosis clinics roughly 20 years ago. Some of my patients came to the clinic and told me that they…

18 Mins

Jul

Moving from The Periphery to The Core of The Matter – Where Does Opicapone▼ Fit in Parkinson’s Disease?

Presented here are highlights of a virtual satellite symposium from the European Academy of Neurology (EAN) 2020 Virtual Congress…

6 Mins

Jul

An Evaluation of the Studies on the Therapeutic Effects of Yoga in People with Dementia

The global population is ageing, and the prevalence of dementia is increasing. Current conventional drug therapy lacks efficacy; therefore…

20 Mins

Jul

Editor's Pick: Current Paradigms to Explore the Gut Microbiota Linkage to Neurological Disorders

The human body harbours a diverse community of symbiotic, commensal, and pathogenic micro-organisms including bacteria, viruses, and fungi…

24 Mins

Jul

Clinical Controversies in Amyotrophic Lateral Sclerosis

Motor neurone disease (MND) encompasses a group of disorders affecting the anterior horn cells and includes the most common form…

18 Mins

Jul

Neuroinfections: Presentation, Diagnosis, and Treatment of Meningitis and Encephalitis

Infections of the central nervous system (CNS) are varied in their causes, presentations, and prognosis…

4 Mins

Jul

Case Report of Schwannomas: Benign Tumour of the Peripheral Nerve Sheath

Schwannomas are benign, painless, firm nodules, 1–2 cm in diameter, that develop from the Schwann cells of peripheral nerve sheaths…

10 Mins

Jul

Neuroinflammation: A Common Line Between the Wnt Pathway and Toll-Like Receptors

Neurodegenerative disorders constitute a worldwide concern attributable to the ageing of the human population.

12 Mins

Jul

Unilateral Facial Palsyin Guillain–Barré Syndrome, A Hyperreflexic Variant Case

Guillain–Barré syndrome (GBS) is a form of rapidly progressive, acute inflammatory demyelinating polyradiculopathy.

21 Mins

Jun

National Institute for Health and Care Excellence (NICE) Guidelines on Cannabis-Based Medicinal Products: Clinical Practice Implications for Epilepsy Management

The ‘treatment gap’ for people with epilepsy is a global health emergency; this is the number of people who need epilepsy treatment but are not…

8 Mins

Jun

A Case Report: Isolated Pontine Lesion in Hypertensive of a Pregnant Patient with Idiopathic Thrombocytopenia

Posterior reversible encephalopathy syndrome (PRES) is a clinical condition characterised by headache, visual disturbances, seizures, and confusion…

18 Mins

Dec

Improving Intravenous Immunoglobulin Dosing in Autoimmune Neuropathies

This symposium took place on Monday 24th June 2019, as part of the 2019 Peripheral Nerve Society (PNS) Annual Meeting in Genoa, Italy.

12 Mins

Aug

Optimism and Opportunities with Anti-CGRP Biologics in Migraine: Where Are We Today?

Migraine is a complex neurological disorder with an approximate global prevalence of 15%. It is characterised by a moderate-to-severe unilateral…

17 Mins

Aug

Editor's Pick: Classification of Pontocerebellar Hypoplasia: Where does it End?

Pontocerebellar hypoplasia (PCH) describes a heterogeneous group of rare neurodegenerative diseases. PCH is characterised by hypoplasia of the cerebellum…

16 Mins

Aug

Seizures in Childhood: Aetiology, Diagnosis, Treatment, and What the Future May Hold

Seizures are one of the most common medical problems affecting children, and epilepsy is the most common chronic neurological condition in children…

15 Mins

Aug

At Physiologically Relevant Concentrations, Valproic Acid and Lithium Carbonate Reduce Oxidative Stress in Human Astrocytoma Cells

There is growing evidence for the connection between mitochondrial alterations in psychiatric disorders and psychiatric symptoms in mitochondrial…

18 Mins

Aug

A Possible Explanation For Neurodegenerative Disease

In 2015, 46.8 million individuals worldwide had a neurodegenerative disease, with 4.6 million new cases being recorded each year.1 Many of these…

17 Mins

Aug

The Autonomic Nervous System: Delineating Historical Landmarks and Their Translation to Target Autonomic Dysfunctions in Multiple Sclerosis

Multiple sclerosis (MS) is first perceived as a disease affecting voluntary motor and sensory systems. The autonomic dysfunctions associated…

16 Mins

Aug

Acquired Language Disorders in Bilinguals

The cases of bilingual aphasia are increasing worldwide, as they also reflect the globally increasing number of individuals speaking more than two…

13 Mins

May

Current Issues in Multiple Sclerosis: Selected Highlights of the ECTRIMS 2018 Congress

It is well established that pregnancy has a clear impact on disease activity in multiple sclerosis (MS); the relapse rate decreases during…

10 Mins

Dec

Management of Fluctuating Parkinson’s Disease: From Science to Clinical Wisdom

This symposium took place at the 4th Congress of the European Academy of Neurology (EAN) 2018 in Lisbon, Portugal, and focussed on the effective…

9 Mins

Aug

Diagnosing Neuromuscular Diseases

The field of neuromuscular diseases (NMD) has evolved at an unprecedented speed over the last two decades. Due to advances in molecular genetics…

16 Mins

Aug

Editor's Pick: Palliative Care in Neurology: Integrating a Palliative Approach to Amyotrophic Lateral Sclerosis Care

This narrative review examines connections between neurology, specialist palliative care, and an integrated palliative approach to care for people living…

16 Mins

Aug

Behçet’s Disease and Neuro-Behçet’s Syndrome

Behçet’s disease is an idiopathic chronic relapsing multisystem vascular-inflammatory disease of unknown origin, which usually presents with orogenital…

14 Mins

Aug

Spatial Patterns of the Tau-Immunoreactive Inclusions in Eight Different Tauopathies are Consistent with the Spread of Pathogenic Tau

Tauopathies are a major group of neurodegenerative disorders characterised by the presence of tau-immunoreactive inclusions in the cytoplasm of neurons…

14 Mins

Aug

Plasmapheresis for Neuromyelitis Optica: A Review from the Transfusion Medicine Specialist’s Perspective

Neuromyelitis optica is characterised by severe visual impairment and neurologic dysfunction, and aggressive plasmapheresis treatment is often recommended.

10 Mins

Jun

Plotting a Better Pathway for Parkinson’s Disease: A New Composite Scale from My PD Journey

A clinical scale that takes a broader, deeper view of Parkinson’s disease (PD) symptoms is the latest milestone in a collaborative effort by My PD…

12 Mins

Mar

Insomnia in the Ageing Population: Characterisation and Non-Pharmacological Treatment Strategies

Sleep problems represent a worldwide health concern among older adults, with an increasing prevalence of multimorbid conditions and a decreased quality…

14 Mins

Aug

Editor’s Pick : Emerging Treatment Options in Migraine

Migraine is a leading cause of disability worldwide. Despite increasing knowledge about its pathophysiology and neurobiology over recent times, treatment…

5 Mins

Aug

The Clinical Development of Cerebrolysin: New Approaches in Stroke Studies. A Commentary to the Cars Study

Additional efficacious treatment options for stroke are urgently needed as thrombolysis and endovascular thrombectomy are too rarely utilised due to the…

14 Mins

Aug

Paediatric Primary Headache: Pharmacological and Non-Pharmacological Treatments

Headaches are common in children and adolescents, and are the most common pain complaint when seeking medical advice.

17 Mins

Aug

Central Nervous System Disease Associated with Major Viral Haemorrhagic Fever Viruses of Public Health Importance: Challenges in Patient Diagnosis, Evaluation, and Management in Resource-Limited Settings

Viral haemorrhagic fever (VHF) viruses cause infectious diseases that are of public health importance. Billions of people from all over the world are at…

10 Mins

Aug

Neurosyphilis: An Important Cause of Recurrent Strokes

Neurosyphilis can manifest as recurrent brain infarction, although not frequently, but can be challenging to diagnose due to atypical presentations.

8 Mins

Aug

Focus on the Endogenous Cannabinoid System in Migraine

Migraine prophylaxis represents a better choice than symptomatic drugs, both for safety and for effectiveness.

16 Mins

Jun

Comprehensive Assessment and Pharmacotherapy of Patients with Chronic Pain Syndrome Due to Diabetic Neuropathy and Postherpetic Neuralgia

Management of chronic pain, usually associated with comorbid conditions, remains challenging. General practitioners, together with multidisciplinary…

11 Mins

Jun

Paradigm Shift for Thrombolysis for Patients with Acute Ischaemic Stroke, from Extension of the Time Window to the Rapid Recanalisation After Symptom Onset

Intravenous thrombolysis (IVT) and intra-arterial thrombolysis (IAT) are useful therapeutic tools to improve functional outcomes after recanalisation of…

16 Mins

Mar

State-Of-The-Art Advances in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is a severe and fatal muscle condition affecting young children. Without interventions, affected boys lose the ability…

13 Mins

Feb

New Developments for Parkinson’s Therapy with COMT Inhibitors

Parkinson’s disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. There are currently…

Dec

Clinical Management of Drug-Induced Dyskinesia in Parkinson’s Disease: Why Current Approaches May Need to Be Changed to Optimise Quality of Life

Parkinson’s disease is a complex, progressive neurodegenerative disorder associated with both motor and non-motor symptoms. Current treatment strategies…

Jul

Brain Health: Translating Scientific Evidence Into Clinical Practice in Multiple Sclerosis

Brain volume loss (BVL) progresses more rapidly in patients with multiple sclerosis (MS) than in healthy individuals, and brain atrophy begins early in…

Jul

Editor’s Pick: Clinical Significance of Apathy in Parkinson’s Disease

Apathy, or lack of motivation, is increasingly recognised as a major factor affecting quality of life and prognosis in Parkinson’s disease (PD)…

Jul

Development and Translation of Therapies for Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterised by widespread loss of lower motor neurons from the spinal…

Jul

Wilson’s Disease: An Inherited, Silent, Copper Intoxication Disease

Wilson’s disease is a rare, autosomal recessive, genetic, copper overload disease, which evokes multiple motor or neuropsychiatric symptoms and liver…

Jul

Multiple Sclerosis: Where Do We Go From Here?

Multiple sclerosis (MS) is the most common cause of neurological disability in young populations after trauma and represents a significant personal…

Jul

Whole Spectrum of Natural Progression of Haemangioblastoma Seen Within a Single Patient: A Very Rare Case Report and Literature Review

This paper reports a rare case of sporadic variation of haemangioblastoma (HB) presenting as multiple lesions within the posterior fossa. A whole…

Jul

Advances in the Management of Transient Ischaemic Attack and Stroke

Among many important advances in the management of transient ischaemic attack (TIA) and stroke are: the updated definition of TIA; risk stratification…

Apr

The Multifactorial Background of Emerging Viral Infections with Neurological Manifestation

The events of the past year have highlighted the continuing importance of emerging virus infections on the diagnosis and treatment of neurological disease.

Jan

How I Treat: Multiple Sclerosis

Multiple sclerosis (MS) is a neurological disorder, characterised by inflammation and neurodegeneration.

Aug

Non-Oral Drug Delivery Strategies: From Early Diagnosis to Advanced Treatments

This educational symposium, sponsored by Britannia Pharmaceuticals Limited, was held during the 1st Congress of the European Academy of Neurology (EAN)…

Aug

Hypothalamic–Pituitary Alterations in Patients With Neurosarcoidosis

Sarcoidosis is a non-caseating, granulomatous inflammatory disorder that can affect the central nervous system (CNS), including the hypothalamic–pituitary..

Aug

Management of Malignant Middle Cerebral Artery Infarction

Malignant middle cerebral artery (MCA) infarcts occur in a small subset of patients with ischaemic strokes and lead to high levels of disability and…

Aug

Clinical Relevance of Cerebral Autoregulation Following Spontaneous Intracerebral Haemorrhage

Hypertensive intracranial haemorrhage is a common neurological emergency in clinical practice.

Aug

Automated Quantification of Stroke Damage on Brain Computed Tomography Scans: e-ASPECTS

Emergency radiological diagnosis of acute ischaemic stroke requires the accurate detection and appropriate interpretation of relevant imaging findings.

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EMJ Innovations 5.1 2021

Neurology

Editor's Pick: Current Paradigms to Explore the Gut Microbiota Linkage to Neurological Disorders

Clinical Profile and Outcome of Children with Acute Central Nervous System Infection in Kerala, India

The Role of Sphingosine 1-Phosphate Receptor Modulators in the Treatment of Multiple Sclerosis

Empowering Physicians to Advance the Future of Alzheimer’s Disease Management and Care

Interview: Professor Michael Barnes

Moving from The Periphery to The Core of The Matter – Where Does Opicapone▼ Fit in Parkinson’s Disease?

An Evaluation of the Studies on the Therapeutic Effects of Yoga in People with Dementia

Editor's Pick: Current Paradigms to Explore the Gut Microbiota Linkage to Neurological Disorders

Clinical Controversies in Amyotrophic Lateral Sclerosis

Neuroinfections: Presentation, Diagnosis, and Treatment of Meningitis and Encephalitis

Case Report of Schwannomas: Benign Tumour of the Peripheral Nerve Sheath

Neuroinflammation: A Common Line Between the Wnt Pathway and Toll-Like Receptors

Unilateral Facial Palsyin Guillain–Barré Syndrome, A Hyperreflexic Variant Case

National Institute for Health and Care Excellence (NICE) Guidelines on Cannabis-Based Medicinal Products: Clinical Practice Implications for Epilepsy Management

A Case Report: Isolated Pontine Lesion in Hypertensive of a Pregnant Patient with Idiopathic Thrombocytopenia

Improving Intravenous Immunoglobulin Dosing in Autoimmune Neuropathies

Optimism and Opportunities with Anti-CGRP Biologics in Migraine: Where Are We Today?

Editor's Pick: Classification of Pontocerebellar Hypoplasia: Where does it End?

Seizures in Childhood: Aetiology, Diagnosis, Treatment, and What the Future May Hold

At Physiologically Relevant Concentrations, Valproic Acid and Lithium Carbonate Reduce Oxidative Stress in Human Astrocytoma Cells

A Possible Explanation For Neurodegenerative Disease

The Autonomic Nervous System: Delineating Historical Landmarks and Their Translation to Target Autonomic Dysfunctions in Multiple Sclerosis

Acquired Language Disorders in Bilinguals

Current Issues in Multiple Sclerosis: Selected Highlights of the ECTRIMS 2018 Congress

Management of Fluctuating Parkinson’s Disease: From Science to Clinical Wisdom

Diagnosing Neuromuscular Diseases

Editor's Pick: Palliative Care in Neurology: Integrating a Palliative Approach to Amyotrophic Lateral Sclerosis Care

Behçet’s Disease and Neuro-Behçet’s Syndrome

Spatial Patterns of the Tau-Immunoreactive Inclusions in Eight Different Tauopathies are Consistent with the Spread of Pathogenic Tau

Plasmapheresis for Neuromyelitis Optica: A Review from the Transfusion Medicine Specialist’s Perspective

Plotting a Better Pathway for Parkinson’s Disease: A New Composite Scale from My PD Journey

Insomnia in the Ageing Population: Characterisation and Non-Pharmacological Treatment Strategies

Editor’s Pick : Emerging Treatment Options in Migraine

The Clinical Development of Cerebrolysin: New Approaches in Stroke Studies. A Commentary to the Cars Study

Paediatric Primary Headache: Pharmacological and Non-Pharmacological Treatments

Central Nervous System Disease Associated with Major Viral Haemorrhagic Fever Viruses of Public Health Importance: Challenges in Patient Diagnosis, Evaluation, and Management in Resource-Limited Settings

Neurosyphilis: An Important Cause of Recurrent Strokes

Focus on the Endogenous Cannabinoid System in Migraine

Comprehensive Assessment and Pharmacotherapy of Patients with Chronic Pain Syndrome Due to Diabetic Neuropathy and Postherpetic Neuralgia

Paradigm Shift for Thrombolysis for Patients with Acute Ischaemic Stroke, from Extension of the Time Window to the Rapid Recanalisation After Symptom Onset

State-Of-The-Art Advances in Duchenne Muscular Dystrophy

New Developments for Parkinson’s Therapy with COMT Inhibitors

Clinical Management of Drug-Induced Dyskinesia in Parkinson’s Disease: Why Current Approaches May Need to Be Changed to Optimise Quality of Life

Brain Health: Translating Scientific Evidence Into Clinical Practice in Multiple Sclerosis

Editor’s Pick: Clinical Significance of Apathy in Parkinson’s Disease

Development and Translation of Therapies for Spinal Muscular Atrophy

Wilson’s Disease: An Inherited, Silent, Copper Intoxication Disease

Multiple Sclerosis: Where Do We Go From Here?

Whole Spectrum of Natural Progression of Haemangioblastoma Seen Within a Single Patient: A Very Rare Case Report and Literature Review

Advances in the Management of Transient Ischaemic Attack and Stroke

The Multifactorial Background of Emerging Viral Infections with Neurological Manifestation

How I Treat: Multiple Sclerosis

Non-Oral Drug Delivery Strategies: From Early Diagnosis to Advanced Treatments

Hypothalamic–Pituitary Alterations in Patients With Neurosarcoidosis

Management of Malignant Middle Cerebral Artery Infarction

Clinical Relevance of Cerebral Autoregulation Following Spontaneous Intracerebral Haemorrhage

Automated Quantification of Stroke Damage on Brain Computed Tomography Scans: e-ASPECTS

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