Neurology

Young adults with rare spinal AVMs show strong recovery after targeted endovascular treatment, guided by MRI and CT imaging of the lesions.

Persistent Epstein-Barr virus antibody levels may help distinguish multiple sclerosis from similar neuroinflammatory diseases.

After 2 weeks, patients in the adjunctive FMT group demonstrated significantly greater reductions in HAMD-24 scores compared with controls (p=0.048), alongside a higher overall reduction rate (p=0.016).

Across the pooled analysis, tES demonstrated a significant moderate therapeutic effect in reducing OCD severity (standardised mean difference: 0.61; 95% confidence interval: 0.37–0.85; p

New research tracks early Parkinson’s symptoms over three years, showing how daily impacts evolve and highlighting the value of wearable monitoring.

New research links sleep disturbances after paediatric brain injury to behavioural difficulties, suggesting sleep could be an important target for early clinical intervention.

Clinical studies suggest zorevunersen could reduce seizures and improve quality of life for children and adolescents with Dravet syndrome.

Administration of prochlorperazine or CLP-257 (or its prodrug CLP-290), significantly decreased seizure frequency in vivo, providing further evidence that enhancing KCC2 function could stabilise neuronal networks.

Researchers use long-read genome sequencing to uncover hidden autism gene variants, improving understanding of genetic causes and advancing precision diagnostics.

Brain imaging reveals sensory amplification in chronic back pain, partially reversible with pain reprocessing therapy.

Antibiotic-treated mice demonstrated significantly smaller lesion volumes and reduced cell death compared with vehicle-treated controls after repeated injury.

Low dose lithium treatment tested in mild cognitive impairment, offering effect size data for future larger trials.

New deep learning model combining X-ray and MRI data shows promise in increasing efficiency of cervical spondylosis diagnosis.

Shared molecular changes in brain and blood may improve major depressive disorder diagnosis and guide personalised therapies.

A large cohort study links smoking habits to Parkinson’s disease risk and all-cause mortality, showing persistent smokers have lower PD risk but quitting improves survival.

A pilot cluster randomised study in Ireland shows structured sensory intervention is feasible in dementia care, with strong staff engagement and device uptake.

The authors concluded that the time until onset of Alzheimer’s disease symptoms could be estimated using a single blood test within a margin of error that may be acceptable for use in clinical trials.

Long-term ublituximab treatment reduces relapse rates and disability progression, reinforcing early intervention strategies in multiple sclerosis care.

Heavy cannabis use linked to reduced brain activation during memory tasks, raising concerns about lasting cognitive health effects.

This study shows that brain age as a biomarker may help diagnose mental disorders earlier, and guide more personalised psychiatric treatment.

New study links semaglutide to rare optic nerve damage, highlighting the need for increased awareness, monitoring, and informed prescribing.

A large prospective study in JAMA finds higher caffeinated coffee and tea intake is associated with lower dementia risk and modestly better cognitive function over decades of follow-up.

National data show cumulative lead exposure may triple Alzheimer’s risk and account for 18% of dementia cases annually.

Long-term trial data suggest speed-based cognitive training with boosters may reduce the risk of dementia diagnosis years later.

A UK trial suggests a ketogenic diet may modestly improve symptoms in treatment-resistant depression, but adherence remains a challenge.

New research links psychotic experiences to early brain ageing, offering clues about psychosis risk in young adults.

Study shows non-brain diseases such as diabetes, hearing loss, and liver disease, account for nearly one-third of dementia cases worldwide.

Cumulative psychosocial stress across childhood and adulthood is linked to higher dementia and stroke risk, partly driven by depression.

Long-term Framingham data show traumatic brain injury in older adults, often caused by falls, is linked to higher dementia-related mortality, with risk rising alongside injury severity.

New imaging evidence shows altered brain networks during cognitive effort in chronic fatigue syndrome and long COVID patients.

New imaging data reveal striking sex differences in Alzheimer’s disease biomarkers, with implications for diagnosis and personalised dementia care.

Notably, higher ventral tegmental area (VTA) activation, but not nucleus accumbens or control region activity, correlated with larger post-vaccination increases in HBV antibody levels (r=0.31, P=0.018)

Discover why deep brain stimulation may be safer than expected and how large scale data could change surgical decision making.

A nationwide Swedish study links long-term air pollution exposure to increased motor neuron disease risk and poorer outcomes.

Long-term trial data show vagus nerve stimulation sustains and even increases benefits for patients with severe treatment resistant depression.

When combined with conventional MEP data, the model achieved 83.3% overall accuracy and 82.3% balanced accuracy in identifying MDD.

Find out how maternal diabetes and birth size may shape multiple sclerosis risk decades later in adulthood across large national cohorts.

A nationwide study reveals that pregnancy acid-suppressive medication does not increase children neuropsychiatric disorder risk over time.

Long-term research links Mediterranean diet patterns with lower Parkinson’s incidence in women younger than seventy one years.

Find out how robot-assisted therapy for autism matches standard treatment outcomes while improving engagement and expanding access in clinical and community settings.

New research shows blood age can directly influence Alzheimer’s progression and memory decline in experimental models.

New research shows social isolation directly speeds up cognitive decline across all demographic groups in older adults.

New research shows how portable monitoring could reshape infant seizure diagnosis and treatment in neonatal intensive care.

New meta-analysis confirms symbol coding tasks remain among the most impaired cognitive tests in schizophrenia.

New trial analysis suggests fewer injections may safely maintain vision in patients with polypoidal choroidal vasculopathy.

Research links PFAS mixtures and genetic susceptibility to increased odds of multiple sclerosis in a large Swedish study.

Long term research links high fat cheese and cream consumption to lower dementia risk in older adults.

Large cohort study reveals elevated meningiomas risk decades after childhood cancer treatment.

Large study tracks how intraventricular hemorrhage influences academic progress from primary school to adolescence.

Blood biomarker p-tau217 helps identify sleep disorder patients at highest risk of cognitive decline.

A UK trial explores immune suppression in early Parkinson’s disease with important lessons for future treatments.

A clinical trial shows home gamma stimulation may safely improve cognitive outcomes in people with early Alzheimer’s disease.

AI analysis of EEG scans helps distinguish frontotemporal dementia from Alzheimer’s disease with high accuracy.

A study reveals how nicotine withdrawal increases pain and opioid use after surgery by altering brain activity.

A major study shows how heat exposure affects early development across six countries. Find out what researchers discovered.

A major study links PTSD to faster brain ageing in WTC responders. Find out what the data shows.

New research reveals surprising strengths linked to mental illness, from creativity to resilience and improved long term wellbeing.

Discover how the brain’s structural networks evolve in five distinct phases across the human lifespan, from childhood to late ageing.

Blood based dementia biomarkers reveal which patients with memory concerns are most likely to worsen.

A new analysis shows how acute dengue infection increases neurological risks, especially in older adults.

New research shows obstructive sleep apnoea may raise Parkinson risk, with early treatment offering potential protection.

A major trial finds metformin helps reduce weight gain in young people treated with antipsychotic medication.

Discover how rare genetic variants significantly raise the risk of ADHD and affect brain development and life outcomes.

Global data reveal persistent burden from headache disorders, highlighting urgent clinical and public health priorities for prevention and management.

New evidence suggests paternal valproate use may increase child neurodevelopmental risk, prompting new clinical guidance considerations.

A new study shows that long sustained-attention tasks detect fatigue in people with multiple sclerosis far more effectively than short cognitive tests.

A major UK study of 309,000 adults links better sleep quality to a lower risk of developing migraines, partly explained by healthier cholesterol levels.

By demonstrating that targeted molecular editing can reverse memory loss in ageing brains, this research opens an entirely new direction for therapies.

Study reveals doxycycline may lower schizophrenia risk in adolescents, offering new hope for mental health prevention.

Study finds traumatic spinal cord injury linked to higher long-term risks of chronic illness, including heart disease and diabetes.

Study reveals cladribine reduces disability progression in Treatment-Naive Relapsing-Remitting MS more so than sphingosine-1-phosphate receptor modulators.

Researchers find early signs of brain damage in rugby players through advanced imaging and biomarker analysis.

Researchers detect hidden signs of awareness in ICU patients using fNIRS brain imaging, reshaping understanding of consciousness.

New research links Obstructive Sleep Apnea to brain microbleeds, suggesting early intervention could reduce neurological and stroke risks.

New research links music for dementia prevention to lower cognitive decline risk and better long-term brain health.

Anxiety research in teenagers shows EEG-fMRI fusion can predict future anxiety, paving the way for personalised prevention strategies.

A UK study reveals how weight and mental illness are linked, with emphasis on long-term weight gain and limited access to care.

AI-driven nerve stimulation shows significant improvement in essential tremor symptoms, offering a noninvasive treatment alternative.

New research finds women with hyperemesis gravidarum face higher risks of depression before and after pregnancy.

The KARMA-Dep 2 trial finds ketamine for depression no more effective than placebo in treating hospitalised patients with major depression.

New research links antipsychotic medication in dementia hospice patients to increased mortality risk.

New genetic research explores whether lowering cholesterol can protect against dementia across major populations.

A GENFI study reveals a new MRI method detects early frontotemporal dementia changes before symptoms or brain shrinkage.

A geographical analysis shows ALS and MS follow nearly identical patterns, suggesting shared environmental influences behind both diseases.

A new trial shows that hearing their mother’s voice helps premature babies build neural connections essential for language.

New analysis reveals a link between posttreatment amyloid levels and clinical improvement in Alzheimer’s treatment outcomes.

ALS risk is heightened in the first two years after traumatic brain injury but does not remain elevated long term, suggesting reverse causality.

Almost a third of severe Long COVID patients are diagnosed with POTS, especially middle-aged women, impacting recovery and quality of life.

This study supports HD-tDCS as a safe, fast-acting, and effective non-invasive option for depression treatment.

Trial shows candesartan cuts migraine days and is well tolerated. Read more to learn about this promising prevention therapy.

Study links sugary drink intake and depression to gut microbiome changes, especially in women, suggesting new prevention strategies.

Skin-to-skin contact in hospital helps very preterm infants develop stronger brain pathways for stress and emotions.

Adaptive brain stimulation proves safe and effective for Parkinson, reducing side effects while maintaining long-term symptom control.

Large-scale observational and genetic analyses reveal that alcohol consumption is associated with higher dementia risk. Genetic evidence contradicts protective effects of light drinking.

A Phase I/II trial of AMT-130 gene therapy slowed Huntington’s disease progression by 75% over 36 months, showing biomarker and functional benefits.

Dementia prevention must start in childhood, with new evidence linking lifelong social adversity to brain decline and disease risk.

Half of critically ill encephalitis patients face poor outcomes within months, but recovery varies by cause. Keep reading to learn more.

International study links seizure-related breathing interruptions to epilepsy mortality risk, paving the way for improved monitoring and prevention.

Updated global criteria standardise diagnosis of vascular cognitive impairment and dementia, incorporating biomarker guidance and preclinical assessment.

Cooler bedrooms and brighter daytimes shown to promote better sleep and wellbeing in people living with dementia, new study reveals.

SLIT2 protein in eye and blood linked to early cognitive decline, paving the way for new dementia tests.

Childhood cognitive skills linked to lower mortality risk, but adversity may weaken these protective effects into adulthood.

Air pollution may drive Lewy body dementia by triggering toxic brain protein clumps, new research shows.

Single-dose MM120 provides fast, lasting anxiety relief in generalised anxiety disorder, paving the way for new treatments.

Frequent use of artificial sweeteners may speed up memory loss and thinking decline, particularly for those with diabetes.

AI speech analysis detects neurological disorders with over 90 percent accuracy, promising rapid non-invasive screening worldwide.

A large cohort study using data from the UK Biobank has found that metabolic syndrome is associated with an increased risk of developing Parkinson’s disease, particularly in individuals with a high genetic predisposition.

Medical cannabis linked to better sleep, mood, and life quality in insomnia patients over 18 months, real-world study finds.

Focal epilepsy study shows most patients need over a year and multiple medications to gain seizure control.

Prenatal pesticide exposure linked to brain abnormalities and motor deficits in children, new MRI study shows.

Over half of chronic pain patients discontinue medical cannabis within a year, highlighting need for individualised care.

Dopamine changes link to psychotic symptoms, suggesting new treatment avenues for mood disorders with psychosis.

A multidimensional framework revolutionises traumatic brain injury characterisation, offering more personalised and accurate care.

Men with dementia show higher mortality and hospitalisation rates than women, according to major US Medicare study.

Tongue coating analysis reveals microbial and metabolic markers to aid Parkinson’s disease diagnosis.

Health care visits rise years before multiple sclerosis diagnosis, suggesting earlier signs and opportunities for intervention.

Prenatal maternal depression alters brain connectivity patterns in children through adolescence, new large-cohort study reveals.

Herpes virus exposure linked to faster rises in dementia biomarkers for ageing women, shedding light on infection’s role.

Study of over one million children finds no link between aluminium in vaccines and autism or chronic illnesses.

Pregnancy does not raise the risk of recurrent artery dissection or stroke in women with prior CeAD, new study finds.

Understand how MRI sign accurately identifies Parkinson’s in complex cases, offering a radiation-free alternative to SPECT scans.

Discover why older adults with insomnia face greater depression risk from inflammation. Keep reading for clinical insights and guidance.

Parental genetics and kidney function partly shape blood-based biomarkers for dementia, underscoring the need for careful interpretation.

Semaglutide and tirzepatide lower risks of dementia, stroke, and death in type 2 diabetes and obesity, new study shows.

Learn how metformin may enhance cognitive function in schizophrenia by regulating energy metabolism and brain connectivity.

Music therapy shows promise for reducing distress in patients with dementia on NHS wards, supporting safer, more compassionate care.

Erythritol at common dietary levels impairs brain endothelial cell function, raising new concerns for cerebrovascular health.

Learn how low-dose IL-2 shows early promise in safely modulating Alzheimer’s biomarkers and immune response.

Ambroxol increased enzyme levels in Parkinson’s dementia patients, but showed no cognitive benefit in a year-long trial.

Longer sleep after concussion is linked to more symptoms and slower recovery in young people, new research finds.

Covert cerebrovascular disease may significantly raise fall risk in older adults, even in the absence of symptoms.

Learn how prenatal tobacco alters teen brain development and behaviour, discover key findings and implications. Read more!

Despite the setback, hope remains, with 138 dementia drugs currently in trials, experts say more effective, safer options may soon emerge.

Blood biomarker sNfL predicts MS relapses up to a year in advance, offering new hope for earlier intervention.

AI tool GPT-4o boosts diagnosis accuracy for nerve disorders, helping non-specialists match expert recommendations in real cases.

Frequent nightmares accelerate ageing and triple risk of early death, highlighting a new target for preventive healthcare.

A routine blood test for insulin resistance can predict which Alzheimer’s patients are at risk of rapid cognitive decline.

Nighttime heart rate variability may reveal hidden risks for stroke, depression, and dementia, years before symptoms appear.

Oral bacteria migrating to the gut may drive dementia risk in Parkinson’s, offering new hope for early intervention.

A large meta-analysis suggests TMS improves clinical outcomes in OCD and nicotine dependence, but the role of symptom provocation needs further study.

Healthy lifestyle choices could reduce the risk of stroke, dementia, and late-life depression in individuals with biologically shorter telomeres.

New research reveals that depression following stroke has a significant long-term impact on survival, recovery, and quality of life.

Find out how depression raises dementia risk throughout life – keep reading for the latest research findings.

Dementia diagnoses decline, but more Americans are living longer with the disease and need ongoing support.

Major study finds no early clinical differences between autistic boys and girls at the time of first diagnosis.

Experimental drug jacifusen shows promise for rare ALS, with some patients experiencing unprecedented recovery and stabilisation.

The study found no significant link between the presence of acute infarction and fatigue.

Long-term consumption of ultraprocessed foods is associated with an increased risk of multiple nonmotor symptoms that often precede a Parkinson’s disease diagnosis.

Aspirin cessation fails to cut cSDH recurrence post-surgery, trial reveals.

Baseline brain circuit activity predicts who benefits most from MDMA, paving the way for personalised psychiatric treatments.

Find out how maternal hypertension affects preterm infant brain development and why early intervention is crucial – read more.

Discover how psilocybin therapy could transform Parkinson’s care – read more about this promising pilot trial and future directions.

Autologous haematopoietic stem cell transplantation outperforms alemtuzumab and ocrelizumab in relapse prevention for relapsing MS.

Tricyclic antidepressants and non-invasive neuromodulation techniques lead updated neuropathic pain treatment guidelines.

Alzheimer’s risk factors impact cognition as early as age 24, study reveals.

Young adults face a low but notable risk of epilepsy after stroke, with risk factors well-predicted by current scores.

Blood pressure control over 48 months cuts dementia risk by 15% in a large clinical trial.

Research reveals that APOE4 and early dementia elevate late-onset epilepsy risk in cognitive decline.

Uncinate fasciculus lesion burden is tied to severe anxiety in MS patients, study reveals.

New study reveals specific oral microbes linked to higher pain scores in women with central sensitisation disorders.

New research shows that opioid-exposed newborns have 5% smaller brain volumes, varying by drug type.

Cognitive phenotyping boosts the accuracy of blood biomarkers in predicting brain amyloidosis in Alzheimer’s diagnosis.

A randomised clinical trial shows that the SMART-CP boosts rehab access for Bangladeshi children with cerebral palsy.

ADHD may increase risk of dementia due to elevated brain iron and neuroaxonal damage in adults.

The TRACK-FA study reveals that stalled spinal cord development in childhood Friedreich ataxia, offering new biomarkers for trials.

The TRANSPORT2 trial finds that tDCS fails to boost poststroke motor recovery, despite safety profile.

Reldesemtiv fails to slow ALS progression in COURAGE-ALS trial, highlighting challenges in ALS treatment development.

Study shows that breastfeeding for at least six months can reduce developmental delays in children.