News

Higher cardiovascular risk may signal increased likelihood of eye disease. Find out more about protecting long-term eye health.

A new study found that rare emotional and physical symptoms occurring during orgasm are uncommon but fall within the normal range for women.

Using large public datasets including TCGA, GEO and GTEx, researchers found that BAZ2B expression was consistently reduced in several cancer types, with particularly marked downregulation in breast cancer.

In a multivariate Cox proportional hazards model, statin therapy was associated with a 52% relative reduction in the risk of death at 30 days.

Adjunctive vitamin D may improve pain, healing, and inflammation in oral lichen planus, with benefits most evident during the first six weeks of treatment.

Adaptive ECG noise filtering preserved QT and QRS intervals better than conventional approaches by tailoring filters to noise presence and type.

A new meta-analysis links elevated neutrophil-to-lymphocyte ratio to higher risk and progression of diabetic nephropathy, highlighting its potential as a clinical biomarker.

Combining a host biomarker with large language model analysis improves lower respiratory tract infection diagnosis in ICU patients, reducing uncertainty.

Axillary ultrasound and MRI guide SLNB decisions in early-stage breast cancer, allowing safe surgical de-escalation in selected clinically node-negative patients.

Find out how an electronic diary improves monitoring of gastroesophageal reflux disease symptoms, and supports personalised management strategies for patients.

Daratumumab-lenalidomide maintenance enhances MRD-negative conversion and reduces progression in multiple myeloma patients regardless of age, race, or cytogenetic risk.

PUFA-rich and Nordic diets reduce liver fat and LDL cholesterol over 12 months, with broader metabolic benefits seen with the Nordic diet.

After 1 year, 13 of 17 patients in the 30 mg group tolerated at least 443 mg peanut protein, compared with none in the avoidance group. Similar improvements were observed in the 300 mg group.

Molecular profiling and matched targeted treatment significantly improved survival in advanced cholangiocarcinoma in a large Italian real-world study.

New data identify age, anti-β2GP1 antibodies, and low C3 as key risk factors for cerebral small vessel disease in systemic lupus erythematosus, highlighting the need for targeted screening and risk stratification.

The results suggest that treatment once weekly with semaglutide could reduce the frequency and duration of hospital admissions for patients at high cardiovascular risk…

In 2026, the beleaguered, aging National Health Service (NHS) of England is on the precipice of major changes in staffing models and digital implementations.

An optimised OFA/iLRP aptamer forms a DNA nanostructure delivering doxorubicin selectively to AML cells, improving efficacy and reducing toxicity in preclinical models.

Children facing economic instability and poor social support in the USA have higher odds of long COVID, highlighting the role of social determinants in child health.

39 studies involving 14 300 participants showed that patients with diabetic nephropathy had significantly elevated NLR levels compared to diabetic controls without nephropathy.

An increased polygenic score for HCM was associated with an 1.1% increase in left ventricular ejection fraction…

NHS opt-out tobacco dependency services boost quit attempts in deprived populations, but success lags, highlighting opportunities to reduce inequalities.

New research shows blood age can directly influence Alzheimer’s progression and memory decline in experimental models.

AI system surpasses radiologists in detecting pancreatic cancer on CT scans, promising earlier diagnosis and better outcomes.

Global modelling study shows the economic burden of diabetes could reach trillions by 2050, with informal caregiving a major, under-recognised cost driver.

Autoclaving peanuts significantly reduces IgE binding and improves tolerability in peanut-allergic individuals, offering promise for safer immunotherapy approaches.

Higher baseline testosterone and favourable testicular histology independently predict sperm retrieval success in men with nonmosaic Klinefelter syndrome undergoing TESE.

Impaired heart rate recovery is a powerful new marker for predicting periprocedural myocardial infarction in elective PCI patients.

A university-based study finds a high prevalence of fibromyalgia symptoms, strongly linked to anxiety, stress, and lifestyle factors among students and staff.

New research shows social isolation directly speeds up cognitive decline across all demographic groups in older adults.

Telling women they have dense breasts increased anxiety and confusion without improving understanding or screening intentions.

Delayed routine infant vaccinations strongly predict missed MMR doses by age 2, raising concern as post-pandemic declines coincide with rising measles cases in the USA.

A decade-long retrospective study shows IgG4-related cholangitis responds well to steroids, with low mortality and no progression to cholangiocarcinoma.

Spatial proteomics analysis shows tertiary lymphoid structures correlate with immunotherapy response and survival in Merkel cell carcinoma.

New research shows EEG and AI can rapidly distinguish major dementia types.

Plasma presepsin outperformed traditional biomarkers in predicting 28-day mortality among patients with UTI-related severe infection in emergency care.

Medication-induced deep sedation in ICU patients is linked to loss of independence; lighter sedation and mobility improve outcomes, study finds.

The device, referred to as hPAM TUT, has a rigid body measuring 90 mm in length and just 17 mm in diameter, making it suitable for handheld use.

New research links contraceptive use, mental health and differing heart risk profiles in women.

Prostate cancer remains the most common cancer in men in the UK, with around 55,000 new cases and 12,000 deaths each year and is currently the most common cancer without a national screening programme.

A novel iPSC-derived lung-on-chip model mimics human alveolar tissue, revealing macrophage-driven tuberculosis responses.

After the first embryo transfer, 48.4% of couples in the preimplantation genetic testing group and 46.2% in the no testing group achieved a live birth, a difference that was not statistically significant.

Patients who survive colorectal cancer face a sustained and increased risk of death from chronic liver disease and cirrhosis long after surgery, according to a large population-based analysis from the United States.

New research shows how portable monitoring could reshape infant seizure diagnosis and treatment in neonatal intensive care.

The authors conclude that recognising postpartum haemorrhage at lower blood loss volumes, alongside abnormal haemodynamic signs, could support earlier diagnosis and treatment…

Researchers have identified serine threonine kinase 10 as a key regulator of platelet function, haemostasis and thromboinflammation.

Adult bacterial meningitis continues to carry high mortality and neurological complications, especially from Listeria, Streptococcus pyogenes, and pneumococcus.

Kidney transplant recipients from socioeconomically disadvantaged neighbourhoods face important inequalities in cancer risk and outcomes…

A large Mendelian randomisation study reveals that higher BMI and IBD causally increase hidradenitis suppurativa risk, providing actionable insights for dermatologists and patient counselling.

The basophil activation test may help identify children at risk of severe allergic reactions to cow’s milk, improving safety during oral food challenges.

A retrospective study identifies clinical, laboratory, and imaging predictors of sepsis and mortality after nephrostomy tube placement in cancer patients.

The NHS has introduced routine chickenpox vaccination using the combined MMRV jab, protecting young children from varicella and reducing illness, hospitalisations, and family disruption across the UK.

CT is one of the most widely used diagnostic imaging tools, but accurately estimating patient radiation dose remains challenging because of wide variation in body size and anatomy.

New meta-analysis confirms symbol coding tasks remain among the most impaired cognitive tests in schizophrenia.

Researchers have identified chromosomal instability in circulating tumour cells as a prognostic and predictive biomarker in metastatic castration resistant prostate cancer.

Global and genetic analyses link low physical activity to rising heart disease mortality, while higher activity levels appear to reduce myocardial infarction risk.

A 10-year hospital study reveals how often prediabetes progresses to type 2 diabetes, and how early intervention can reverse risk.

Elevated serum lipoprotein(a) levels are linked to poorer survival outcomes in pancreatic cancer, highlighting its potential as a stable prognostic biomarker.

Integrated structural and functional MRI identifies brain-based biomarkers that distinguish active from remissive Crohn’s disease and correlate with gut inflammation.

Adjunctive NB-UVB phototherapy improved disease control in chronic plaque psoriasis patients with secondary loss of response to adalimumab.

A Japanese cohort study has identified distinct liver enzyme trajectories in early adulthood that are strongly associated with the risk of developing type 2 diabetes.

New data show that minipuberty hormone levels in Turner syndrome can signal early ovarian function, supporting more informed fertility counselling in infancy.

At ASH 2025, investigators reported early results from the first-in-human phase 1 inMMyCAR study evaluating KLN-1010, an investigational in vivo gene therapy…

New evidence shows human rhinovirus can directly infect the lower lungs and cause pneumonia in adults, challenging its reputation as a mild cold virus.

Tai chi may improve long-term sleep in middle-aged and older adults with chronic insomnia, providing a safe and accessible alternative to CBT-I.

The incidence of early-onset colorectal cancer has been increasing worldwide, a trend that has coincided with growing intake of ultraprocessed foods.

Among patients treated in the first-line setting, the overall response rate was 57.1%, compared with 38.1% in those treated in the second line or later.

Genetic analysis shows higher BMI increases hidradenitis suppurativa risk, while smoking evidence is inconclusive. The study also supports a causal link with IBD.

Starting dialysis with a less intensive schedule may help preserve remaining kidney function without increasing risks, according to a new study comparing dialysis approaches.

A Canadian real-world study reveals high oral corticosteroid exposure in patients with severe chronic rhinosinusitis with nasal polyps prior to biologic therapy.

A large retrospective study shows GnRH antagonist protocols yield more oocytes than PPOS in young women at high risk for low retrieval.

Canadian patients with hereditary angioedema report reduced anxiety, fewer attacks, and improved quality of life with long-term subcutaneous C1 inhibitor therapy.

Access to blood transfusions emerged as the most highly valued service, with a mean standardised importance score of 20.53.

Baseline eosinophil levels and early blood count changes may help predict survival and response in metastatic renal cell carcinoma patients treated with nivolumab.

Ants produce diverse, targeted antimicrobial compounds that inhibit drug-resistant pathogens, including Candida auris, offering insights for new antibiotics.

Researchers have developed a new prediction tool that could help clinicians better assess whether complete tumour removal is achievable in women with advanced epithelial ovarian cancer.

A multi-omics study identifies causal genes and biological subtypes of Long COVID, revealing new therapeutic targets for personalised care.

Rare inherited genetic variants linked to mucin glycosylation and DNA repair significantly increase familial lung cancer risk, offering new targets for early detection.

A proof-of-concept trial shows novel sarcoidosis PET/CT tracer detects inflammatory activity, supporting further clinical evaluation.

New real-world data suggest 5:2 intermittent fasting may offer modest cardiovascular benefits over calorie restriction in adults with overweight or obesity.

Meta-analysis shows diabetes increases male infertility risk, with inflammation identified as a key underlying mechanism.

A large study found fewer mental health and cardiovascular events following the autumn daylight saving time clock change in England.

By broadening definition of success to include sustained low-level HBsAg with suppressed HBV DNA, we can recognize clinically meaningful responses that improve patient outcomes, even without full antigen clearance.

The study included 202 adults undergoing cardiac surgery at 11 Australian tertiary hospitals between August 2021 and April 2024.

New research identifies age, anti-β2GP1 antibodies, and low complement C3 as key risk factors for cerebral small vessel disease in systemic lupus erythematosus.

Lower ovarian reserve was significantly associated with accelerated pace of aging and higher methylation risk scores for cardiovascular and metabolic disease.

Vixarelimab significantly reduced itch severity and improved skin clearance in patients with prurigo nodularis in a phase 2b randomized clinical trial.

International panel of anaphylaxis experts develops guidance for non-medical personnel to correctly identify patients with acute allergic reactions that require epinephrine administration.  

A new study identifies APOC1 and NOP16 as potential prostate cancer biomarkers that may improve early diagnosis and complement current PSA testing.

Most adolescents maintained stable mental health through the COVID-19 pandemic, despite widespread concerns about rising depression, according to a large US cohort study.

New trial analysis suggests fewer injections may safely maintain vision in patients with polypoidal choroidal vasculopathy.

Researchers have created a highly detailed spatial multiomic atlas to date of glioma tumour microenvironments.

New research shows resilience partially offsets financial toxicity and improves quality of life in patients with primary liver cancer, highlighting the importance of psychosocial support.

Sequential embolisation and renal cryoablation shows high efficacy and low severe adverse events in patients with renal masses over 3 cm.

Colonic stent placement as a bridge to surgery shows similar survival to emergency resection while reducing stoma rates in obstructive colorectal cancer.

New genetic evidence suggests that people with an inherited tendency towards blood clots may be at higher risk of developing long COVID.

Curcumin supplementation modestly lowers systolic blood pressure in adults with prediabetes and Type 2 diabetes.

Novel multistage malaria vaccine demonstrates over 50% efficacy following controlled human malaria infection, supporting further trials in children.

Research links PFAS mixtures and genetic susceptibility to increased odds of multiple sclerosis in a large Swedish study.

New trial analysis shows COPD treatment withdrawal, including LAMA and ICS discontinuation, can trigger early exacerbation risk.

By reconstructing a fetal liver–specific niche, FLOs enable simultaneous development of hepatic and hematopoietic lineages, revealing cross-talk essential for understanding human liver development and immune injury.

An inflatable device may reshape prone care by improving safety and efficiency in busy intensive care units.

RA patients positive for anti-EBV EA-DR IgG antibodies show higher ACPA levels and increased disease activity, suggesting a link between Epstein–Barr virus immune responses and rheumatoid arthritis.

Close relatives of azoospermic and oligozoospermic men showed the highest all-cause and cause-specific mortality risk, including deaths attributed to cardiovascular disease and congenital conditions.

New research shows combining biomarkers and genetics may dramatically improve heart disease risk assessment and prevention strategies.

Long term research links high fat cheese and cream consumption to lower dementia risk in older adults.

A combined ultrasound and CT model accurately predicts spontaneous stone passage in ureteral stones ≤10 mm, supporting safer conservative management decisions.

Sea saline nasal irrigation lowers bacterial colonisation and incidence of acute upper respiratory infections in children.

More than 386,000 people waited longer than six weeks for testing, accounting for around one in five patients on diagnostic waiting lists.

3D bioprinting enables realistic human skin models and may transform research into chronic inflammatory skin diseases.

Emerging evidence highlights psilocybin as a potential therapy for treatment-resistant OCD, while cannabinoids show limited efficacy.

A multi-species synbiotic supplement has led to measurable improvements in weight, metabolic control and cardiovascular risk markers in elderly people with type 2 diabetes.

High airway TSLP levels identify a subset of severe asthma patients with type 2 inflammation, mucus plugging, and airway remodelling despite corticosteroid treatment.

AI-enhanced ECG screening uncovers silent liver cirrhosis, enabling earlier diagnosis and intervention in routine primary care.

Large cohort study reveals elevated meningiomas risk decades after childhood cancer treatment.

ASAS-PerSpA study finds Japanese patients with axial psoriatic arthritis have lower disease activity and better function than other regions, with notable differences in treatment patterns.

This new resource aims to change that by providing a detailed framework for understanding how different cancers maintain their telomeres and where their weaknesses lie.

Left atrial appendage closure causes a short-term rise in atrial pressure, but no adverse changes in heart structure or biomarkers were seen during follow-up.

Being vaccinated against COVID-19 was associated with a lower risk of hospitalisation, severe maternal disease and preterm birth, regardless of the COVID-19 variant time period, the study found.

Baloxavir significantly reduces hospitalisations in influenza outpatients compared with oseltamivir, highlighting its value during flu season.

Survey study shows COVID-19-related behavioral changes led to delayed colorectal cancer diagnosis and more advanced disease, highlighting the importance of maintaining screening during health crises.

New epidemiological data reveal long serial intervals and sustained scabies transmission in Europe, highlighting how modest prevention could curb epidemic growth.

Nationwide data reveal increasing PCI use after TAVR with low complication rates and important planning implications.

A novel form of chest X-ray imaging could help clinicians detect pneumothorax more quickly and with greater confidence.

Robot-assisted radical prostatectomy was linked to significantly fewer short-term complications than open surgery in a large nationwide French cohort study.

The nSOFA score predicts prolonged mechanical ventilation in newborns with NRDS. Early risk stratification may improve NICU care and outcomes.

Large study tracks how intraventricular hemorrhage influences academic progress from primary school to adolescence.

Between 2011 and 2021, 7,322 men were diagnosed with germ cell cancer in Sweden and Norway.

New research suggests flavanol-rich foods, such as cocoa, may help protect blood vessel function during prolonged sitting.

Interview study shows injectable on-demand treatments for hereditary angioedema may delay care and negatively impact quality of life, highlighting demand for oral options.

A long-term study shows that recurrence beyond the Milan criteria, rather than recurrence itself, drives poorer survival after curative hepatocellular carcinoma resection.

A scoping review shows machine learning models may help predict response to biologic and targeted synthetic DMARDs in rheumatoid arthritis, though validation gaps remain.

Researchers have identified a molecular pathway that helps explain why certain subtypes of triple negative breast cancer are more likely to spread to bone.

The WHO releases 40 evidence-based recommendations and six good practice statements for preventing, diagnosing, and treating infertility.

A targeted physiotherapy approach has been shown to deliver sustained improvements in people with chronic disabling low back pain.

A randomized trial shows combined water exchange and cap-assisted colonoscopy shortens cecal intubation time and reduces pain in unsedated procedures.

High-throughput proteomics identifies inflammatory clusters and biomarkers associated with disease severity and treatment response in bullous pemphigoid.

A randomised trial shows transcutaneous tibial nerve stimulation reduces catheter-related bladder discomfort and improves early recovery after urologic surgery.

Study shows that exhaled volatile organic compounds, including propanoic and nonanoic acids, could be used as non-invasive biomarkers for asthma.

These findings indicate that the low-dose CT component of PET/CT, already performed as part of routine prostate cancer care, can reliably provide information relevant to bone health.

Researchers uncover combined energy, immune, and vascular disruptions that help explain the complex biology of ME/CFS.

Investigators describe this as the largest study to date linking thromboinflammation biomarkers with thrombosis risk in myeloproliferative neoplasms.

NHANES data show glycaemic status and macronutrient intake are linked to sleep duration, sleep disorders, and sleep quality.

A clinical trial shows immune-targeted therapy tailored to sepsis subtypes improves organ function by day 9, offering a new approach to treatment.

Study shows DAAs and interferon offer similar long-term protection against hepatocellular carcinoma after hepatitis C cure and introduces a nomogram to predict 8-year HCC risk.

Study reveals digital health literacy includes navigation, appraisal, and confidence, not just basic online skills.

Global meta-analysis highlights nutrient differences and growth patterns in vegetarian and vegan versus omnivorous diets.

Several widely used food preservatives have been linked to a higher risk of cancer according to a large French study.

WHO’s review of studies from 2010–2025 confirms vaccines, including thiomersal-containing ones, are not associated with autism.

A new study shows that grip strength cannot be used as a proxy for core muscle endurance in axial spondyloarthritis, highlighting the need for targeted core assessments.

A Pan-European study reports high rates of addictive behaviours among patients with chronic skin diseases, linked to poorer quality of life and key demographic factors.

Blood biomarker p-tau217 helps identify sleep disorder patients at highest risk of cognitive decline.

A nasal pressure technique significantly reduces pain during urinary catheterisation, offering a simple, non-pharmacological option for patient comfort in the ED.

New meta-analysis finds e-cigarette use may increase the risk of heart attack and stroke, even after adjusting for cigarette smoking.

This combined model achieved a high level of accuracy, suggesting that imaging data alongside basic clinical information could be effective for screening.

A UK trial explores immune suppression in early Parkinson’s disease with important lessons for future treatments.

Researchers analysed survey responses from more than 1,000 adults taking part in a large multisite trial of advance care planning.

High HbA1c variability is independently associated with poorer neurocognitive outcomes in children with type 1 diabetes.

Very low-dose multi-nut oral immunotherapy significantly increased tolerance in children with multiple nut allergies, with a favourable safety profile and no epinephrine use.

Phase II ELMWOOD trial shows elafibranor is well tolerated and improves liver biochemistry and pruritus in primary sclerosing cholangitis, supporting further trials.

A clinical trial shows home gamma stimulation may safely improve cognitive outcomes in people with early Alzheimer’s disease.

A six-year cohort study shows low muscle strength, not sarcopenia, is linked to increased falls risk in patients with rheumatoid arthritis, highlighting the importance of functional assessments.

New research shows how catheter based debanding may change care after pulmonary artery banding in infants.

Inflammatory molecules circulating in the blood may worsen disease symptoms and points to new opportunities for targeted therapy.

New Global Burden of Disease 2023 data show lower respiratory infections still cause 2.5 million deaths yearly, with children and older adults most affected.

A retrospective cohort study shows that gastrointestinal involvement in granulomatosis with polyangiitis is linked to higher disease activity, earlier relapse, and a threefold increase in mortality risk.

Most systemic therapy-naïve patients with moderate-to-severe atopic dermatitis or psoriasis in Germany wish to escalate treatment, with clear preferences for administration route.

AI analysis of EEG scans helps distinguish frontotemporal dementia from Alzheimer’s disease with high accuracy.

A large NHANES analysis shows the red cell distribution width-to-albumin ratio is strongly associated with diabetic kidney disease risk in adults with diabetes.

Chronic bronchitis affects nearly 10% of adults in low- and middle-income countries, with links to worse respiratory outcomes.

A study has found that the way medical images are prepared before analysis can have a significant impact on the performance of deep learning models.

Find out more about early evidence supporting biomarker-guided cardioprotection in patients receiving anthracycline therapy.

Researchers have developed a genomic model that could improve predictions of long-term recurrence in a common form of breast cancer.

A highly accurate AI model improves prediabetes prediction by integrating antioxidant status with standard risk factors.

A randomized controlled trial shows that the TNF inhibitor etanercept improves cerebral blood flow, vascular reactivity, and endothelial function in elderly patients with rheumatoid arthritis.

A phase 2 trial finds tinengotinib demonstrates anti-tumour activity in previously treated advanced cholangiocarcinoma with FGFR alterations.

Review paper concludes that stem cells and growth factors are effective in treating diabetic foot ulcers. But improved treatment protocols are needed before wider clinical adoption.

Discover how magnesium supplements showed no measurable arrhythmia benefit in a major ICU study using causal methods.

Critically ill patients with systemic lupus erythematosus show reduced ICU survival, driven largely by renal dysfunction, with glucocorticoids potentially mitigating mortality risk.

A 3-year study in Israel shows pooled-saliva cCMV universal screening identifies hidden infections in newborns, enabling early treatment and improving outcomes.

A large, multiethnic study reveals distinct facial microbiota patterns in adolescents with acne, identifying key bacterial species linked to acne pathology.

A major cohort study finds that inadequate vitamin D in pregnancy may raise the risk of early dental caries in children.

Doctors may not need to avoid steroids before biopsy in patients with a common aggressive lymphoma, according to a new study.

CT imaging features including appendicolith, appendiceal diameter, fat stranding, and periappendiceal air help identify patients at risk of complicated acute appendicitis.

New research suggests routine blood-based inflammation markers could help predict which men with enlarged prostates are likely to develop more severe symptoms.

A large USA study finds social media use is linked to increasing inattention symptoms in school-aged children over 4 years.

A study reveals how nicotine withdrawal increases pain and opioid use after surgery by altering brain activity.

The UKHSA has detected an inter-clade recombinant mpox virus in England; vaccines remain effective and risk to the public is low.

A new multinational study reports that rifaximin use in cirrhosis and hepatic encephalopathy is linked to significantly higher risks of antimicrobial resistance and severe infections.

A major study examines ten-year heart changes in marathon runners, revealing reassuring findings for recreational endurance athletes.

Real-world data show switching to IL-17 inhibitors after TNF inhibitor failure improves treatment retention compared with TNF cycling in psoriatic arthritis.

A major international trial reports no difference in outcomes when using higher vs lower initial oxygen levels for preterm resuscitation in extremely preterm infants.

New intranasal BPZE1 vaccine is safe and reduces Bordetella pertussis colonisation, offering hope for whooping cough prevention.

A new Nordic study reports no clear increase in major congenital malformations among infants exposed to topical retinoids in early pregnancy.

Researchers report that yoga and general exercise deliver similar sleep outcomes for women managing urinary incontinence.

New research identifies a specific monocyte gene signature that predicts mortality in IPF, offering potential targets precision medicine.

A major study shows how heat exposure affects early development across six countries. Find out what researchers discovered.

Novel oral GRK2-biased β2 adrenergic receptor agonists show potential for safer glucose management and obesity treatment.

Large PBC cohort shows current liver stiffness measurement >10 kPa predicts hepatic decompensation, outperforming biochemical response or LSM trajectory.

A study demonstrates how AI transforms bionic hand function, improving precision and reducing effort for amputees.

A hybrid AI-human scoring system delivers expert-level accuracy in ulcerative colitis endoscopic assessment while reducing human review by 81 percent.

Meta-analysis finds sperm retrieval success in nonmosaic Klinefelter syndrome similar in adolescents and adults, with possible decline only after age 40.

Women with eczema or other atopic skin conditions may face greater risks of implant-related problems after breast reconstruction, according to a new study led by researchers in Texas.

A large study of 1,100 adults shows how nasal microbiome structure influences Staphylococcus aureus carriage.

New research shows metabolic liver disease is linked to increased androgenetic alopecia risk, with stronger effects in women and those with unhealthy lifestyle patterns.

A new rapid, low-cost sequencing method delivers four-hour UTI diagnosis with high accuracy, detecting pathogens missed by routine tests and improving antibiotic decision-making.

Gas stoves are a major source of indoor nitrogen dioxide, raising exposure levels WHO guidelines for millions of people.

Retrospective study in 755 children shows how a deep-learning algorithm can support clinicians correctly diagnose paediatric elbow fractures, although further developments are required.

A major study links PTSD to faster brain ageing in WTC responders. Find out what the data shows.

Researchers emphasize that these results, together with previous evidence, point to a growing need for stricter controls on synthetic phenols.

A new ANAcare pathway offers clinicians practical, harmonised steps to apply the latest guidelines for diagnosing IgE-mediated food allergy.

New research confirms the GOLDEN model reliably predicts HBsAg loss in interferon-treated chronic hepatitis B patients, supporting more personalized treatment strategies.

Severe sleep loss in pregnant mice depletes daughters’ ovarian germ cells via ferroptosis, partly reversible with a ferroptosis inhibitor, raising concerns for future fertility.

The findings provide reassurance amid growing global use of drugs such as semaglutide and tirzepatide.

The WHO World Malaria Report 2025 highlights gains in malaria control, ongoing challenges in Africa, and lifesaving interventions.

Fibroblasts fuel skin and systemic inflammation via a CXCL10–glycolysis axis in dermatomyositis, offering new metabolic treatment opportunities.

Early weight management in childhood significantly reduces the risk of developing coronary heart disease later in life.

Escalating antimicrobial resistance has been identified among urology inpatients in a new study from a Turkish tertiary centre, highlighting urgent stewardship needs.

New data show that 28% of UK GPs are using AI tools to streamline admin tasks, reduce burnout, and improve patient care.

New research reveals surprising strengths linked to mental illness, from creativity to resilience and improved long term wellbeing.

Researchers have developed a new strategy that allows engineered T cells to recognize and respond to a single tumour antigen through two coordinated mechanisms.

A prospective study finds that using both diffusion-weighted MRI and spectral Doppler ultrasound significantly improves classification of benign and malignant salivary gland tumours.

A new US Drug Allergy Registry report outlines standardised paediatric antibiotic allergy testing protocols to curb unnecessary labels and harmonise research.

Bioinformatics work identifies FAM72A–D as powerful prognostic markers in liver cancer and unveils a compact FAM72 risk score that outperforms existing gene models.

New review highlights major advances in HIV and STI prevention, diagnostics, and integrated service delivery, urging a unified approach to meet 2030 global goals.

Learn how a pilot trial shows low-frequency electrical stimulation with exercise enhances local bone outcomes in premenopausal women.

Discover how the brain’s structural networks evolve in five distinct phases across the human lifespan, from childhood to late ageing.

A phase 3 trial shows dupilumab significantly improves quality of life in omalizumab-naïve patients with chronic spontaneous urticaria.

Combining glecirasib and sitneprotafib shows encouraging efficacy and safety in patients with KRAS G12C-mutated NSCLC.

Scientists used a chemotherapy-free stem cell approach to reverse type 1 diabetes in mice, restoring insulin production and immune balance without long-term medication.

A new BSI-CIPN report warns that UK clinical immunology and allergy services are critically understaffed, calling for urgent national workforce planning and investment.

Silencing S100A11 protects against steatosis, inflammation and fibrosis in murine MASH, uncovering HK2 as a key metabolic driver and potential therapeutic target.

A large Norwegian study shows that higher cardiorespiratory fitness is linked to a significantly lower long-term risk of urinary tract, bladder, and kidney cancers.

Blood based dementia biomarkers reveal which patients with memory concerns are most likely to worsen.

A new review highlights kefir-derived peptides, probiotics and kefiran as promising natural strategies for bone health and osteoporosis prevention.

A world-first personalised CRISPR base-editing therapy has shown promising early results in an infant with CPS1 deficiency, demonstrating the potential of rapid, bespoke gene-editing treatments for ultra-rare genetic diseases.

Garsorasib shrank tumours in nearly half of patients with KRAS G12C pancreatic cancer and showed manageable side effects.

IMCAS World Congress 2026 unites global dermatology experts to explore advances in science, aesthetics, and complication management across lasers, dermatology, and injectables.

New phase 3 trial finds ivarmacitinib ointment provides rapid, lasting relief from mild-to-moderate eczema with a favourable safety profile.

New research shows a quick neck ultrasound may identify older men at increased risk of heart failure.

A new study highlights oxidative and neuroimmune changes in diabetic urinary incontinence, identifying 4-HNE as a key biomarker differentiating diabetic and non-diabetic cases.

PS-OCT reveals distinct scleral fibre changes in pathologic myopia, offering new clues to prevent vision loss.

Experts call for consistent, specialist care throughout life to prevent complications and improve outcomes for people with sickle cell disease.

A rare case of ABPA presenting as pyopneumothorax highlights the need for early recognition of pleural complications in asthmatic patients.

High-dose aluminum adjuvant Imject Alum induces immune-mediated liver inflammation and fibrosis in mice, offering a new preclinical model that mirrors human cirrhosis biology.

BSR has published an updated guideline on the safe use of csDMARDs, introducing new evidence, paediatric guidance, and risk-adaptive monitoring across the full life course.

Engineered herpes virus targets glioblastoma cells, destroying tumours while activating immune defences in preclinical brain cancer models.

New test shows high sensitivity for tuberculosis, providing a faster, near-point-of-care option for early detection and prevention.

Early-stage primary biliary cholangitis shows distinct blood lipid changes tied to inflammation and fibrosis, offering clues to disease activity and potential new biomarkers.

A large retrospective study shows JAK2 gene fusion occurs in both aggressive and indolent cutaneous T-cell lymphomas, offering new insight into diagnosis and targeted treatment.

An automated MRI decision aid (ProAI) improves detection of clinically significant prostate cancer, boosting accuracy and cutting radiology workload by 32%.

Over half of patients with severe asthma discontinued oral corticosteroids while maintaining disease control, major study finds.

Phase 1 trial shows single-fraction stereotactic breast irradiation is safe and effective

A prospective multicenter study shows an MRI-based AI tool can accurately distinguish PD, MSA and PSP, with results confirmed by neuropathology.

Gold-standard clamp trial shows metformin fails to improve insulin resistance in type 1 diabetes, highlighting unmet treatment needs.

AI missed nearly one-third of breast cancer cases in a new study, but diffusion-weighted MRI detected most of these overlooked tumours, especially in dense breast tissue.

NHS England has issued a national alert after penicillin allergies were mistakenly recorded as penicillamine allergies, putting patients at risk of severe anaphylaxis.

A new review finds statins remain safe and effective in MASLD, while evidence for PCSK9 inhibitors is promising but still limited.

Research shows moderate coffee consumption may help slow biological ageing in people with severe mental disorders.

Cardiac involvement was found in 35% of patients with EGPA, with pericarditis, myocarditis, and coronary vasospasms driving worse disease activity and prognosis.

Global maternal deaths fell 41% since 2000, driven mainly by improved maternity care, with contraception and falling fertility also contributing.

WELSH pictorial tool correlates strongly with haemoglobin changes in severe pregnancy anaemia.

Novel mRNA peptibody therapy reduces bacterial load and inflammation in preclinical MDR pneumonia models, offering a new approach to antibiotic resistance.

Swedish study shows patients with stage IIC melanoma have poorer survival than stage IIIA, highlighting need for closer follow-up and treatment.

USA adults living with heart failure have more than doubled since 1988, with risk factors shifting from hypertension and cholesterol to obesity, diabetes, and kidney disease.

Sequential therapy shows poorer outcomes in upper tract urothelial carcinoma than bladder cancer, highlighting the need for more effective first-line treatments.

Polyphenols in fruits, vegetables, and tea may reduce cardiovascular risk, according to 11-year TwinsUK study with urine metabolite data.

A new analysis shows how acute dengue infection increases neurological risks, especially in older adults.

Donor type strongly influences survival, relapse risk, and GVHD after high-risk acute myeloid leukaemia stem cell transplantation.

Researchers uncover how diabetes impairs nerve regeneration and propose potential therapies to restore nerve repair and function.

Blood proteomics uncovers systemic immune changes across inflammatory skin conditions.

Chinese surgeons have performed the first living pig-to-human liver xenotransplant, showing that a gene-edited porcine liver can support human function for weeks.

Find out how an AI screening model greatly increases transthyretin cardiac amyloidosis diagnoses across a major health system.

Exc A large cohort study from Jinan, China suggests spring IVF cycles yield higher live birth rates than winter, though early miscarriage risk also increases.

A modelling study shows syphilis rapid-test algorithms differ widely in missed cases, overtreatment and cost, with optimal strategy varying by population.

A phase 1b/2a trial reports that stapokibart is well tolerated and improves symptoms in children aged 6–11 years with moderate-to-severe atopic dermatitis.

Find out how shifting demographics and modifiable risks are accelerating the global cardiovascular disease burden.

This study reports early outcomes of percutaneous kidney-sparing surgery for upper tract urothelial carcinoma, highlighting feasibility, recurrence rates, and follow-up needs.

Depression and anxiety increase asthma attack risk in adults, highlighting need for targeted care in those with comorbid mental health disorders.

New research shows obstructive sleep apnoea may raise Parkinson risk, with early treatment offering potential protection.

New study shows low LDL cholesterol is associated with higher type 2 diabetes risk, regardless of statin therapy, suggesting biomarker potential.

A French national study has identified eight emerging food allergens frequently causing anaphylaxis but not included in EU labelling rules.

A major review suggests coffee’s bioactive compounds may help lower liver cancer risk, though benefits vary by intake, preparation method and individual lifestyle factors.

Researchers used a virtual clinical trial to test psychedelic responses in coma patients. Find out what they discovered.

New study finds early use of secukinumab in psoriatic arthritis offers no significant advantage over standard step-up treatment after one year.

Comprehensive umbrella review maps 227 non-genetic miscarriage risk factors, identifying 45 with suggestive evidence and highlighting urgent research gaps.

New multicomponent programme reduces infection-related maternal deaths and severe illness in Malawi and Uganda by supporting early detection and treatment.

A new longitudinal study finds that many adolescents with IBS struggle to manage complex treatment plans, highlighting key barriers to effective self-management.

A new trial finds maternal prebiotic supplementation during pregnancy does not prevent atopic dermatitis in high-risk infants at one year of age.

Men receiving a penile prosthesis during prostate cancer surgery showed faster sexual recovery and better satisfaction than those treated years later.

Find out how higher baseline blood pressure leads to stronger renal denervation responses in patients with uncontrolled hypertension.

A new meta-analysis finds that simple, low-cost text message interventions can improve short-term blood sugar control in adults with diabetes.

A new milk allergy therapy protocol lowers the severity of gastrointestinal reactions during OIT, improving safety for patients.

A new study suggests that the cholesterol-regulating protein PCSK9 may serve as a sensitive early biomarker for autoimmune liver diseases, helping identify patients even when routine liver tests appear normal.

New research reveals that low intensity smoking still drives major cardiovascular risks. Find out what the data shows.

Study finds body mass index does not affect incidence or progression of distal interphalangeal joint osteoarthritis in rheumatoid arthritis patients.

Most women lack essential knowledge about menopause, a new UCL study finds.

Sorfequiline, combined with pretomanid and linezolid, shows superior efficacy and safety in drug-sensitive TB, supporting its potential role in ultra-short treatment regimens.

A large USA study found hundreds of undiagnosed familial hypercholesterolemia cases through genetic sequencing, showing clinical tests often miss this treatable risk.

Lupus-like disease linked to MDS/CMML shows distinct features and poor response to standard treatment, improving with clone-directed therapy.

New five-year study results highlight durable outcomes and symptom improvement after transcatheter mitral valve replacement therapy.

Smoking and hysterectomy raise the risk of vaginal mesh erosion after POP surgery, according to a new systematic review and meta-analysis.

Women show larger improvements in symptoms and wellbeing after lung volume reduction, despite similar physical changes to men.

A major trial finds metformin helps reduce weight gain in young people treated with antipsychotic medication.

UK Biobank metabolomic data on 500,000 people could detect disease years early and guide prevention and personalised care.

A 10-year study shows allergen immunotherapy provides lasting symptom relief in local allergic rhinitis and reduces the risk of asthma and new sensitizations.

New research shows that blood types A and B are linked to a higher risk of autoimmune liver disease.

Discover how rare genetic variants significantly raise the risk of ADHD and affect brain development and life outcomes.

A new study shows joint hypermobility impairs proprioception but does not reduce strength or functional stability, highlighting the need for targeted neuromuscular training.

New research shows that skipping ultrasound and hormone monitoring in selected frozen embryo transfer cycles does not affect pregnancy outcomes.

Ultra-processed foods harm health and raise chronic disease risk. Experts call for regulation, warning labels, and support for minimally processed foods.

Global research finds that gut microbiota dysbiosis strongly correlates with rising inflammatory bowel disease rates worldwide.

GLP-1 agonists are more often prescribed for hidradenitis suppurativa patients with obesity, diabetes, and other metabolic conditions.

Certain cancer drugs, including CDK4/6, EGFR, VEGFR, and BRAF inhibitors, may raise the risk of progressive kidney dysfunction over two years.

A new score based on the 6-minute walk test helps predict serious outcomes in lung disease by combining symptoms, oxygen use, distance and oxygen levels.

A breakthrough AI system enhances breast cancer tissue interpretation, boosting accuracy and supporting faster, more reliable clinical diagnoses.

Gestational diabetes in pregnancy changes the gut microbiome of newborns, increasing bacteria linked to inflammation and potential long-term health risks.

A newly reported fatal case of delayed anaphylaxis following beef consumption highlights the growing impact of alpha-gal syndrome.

Many people with primary biliary cholangitis are not receiving recommended alkaline phosphatase monitoring, and adherence is markedly higher among those under specialist care.

Global data reveal persistent burden from headache disorders, highlighting urgent clinical and public health priorities for prevention and management.

New trial shows high-intensity exercise can ease pain and fatigue in systemic sclerosis, improving quality of life and physical function after just 12 weeks.

A study of over 86,000 adults across Europe finds that speaking multiple languages is associated with healthier ageing and lower risk of accelerated ageing.

Validated dataset with 14,441 clinicopathologic and genomic reports supports myeloid neoplasm diagnosis and research globally.

The latest UKHSA winter surveillance bulletin shows flu activity rising unusually early, while COVID-19 remains low and RSV begins to increase.

Chronic hepatitis C infection has been linked to a higher risk of pancreatic cancer.

A study shows adding oral ivermectin to permethrin improves cure rates and speeds symptom relief in children with persistent scabies, with regular follow-up over several months.

New evidence suggests paternal valproate use may increase child neurodevelopmental risk, prompting new clinical guidance considerations.

Researchers identify ALYREF as a dual-role biomarker in bladder cancer, linked to aggressive disease yet improved immunotherapy response.

Although genetic analysis shows little direct link between chronic respiratory and cardiovascular diseases, shared factors like smoking and inflammation drive risk in both conditions.

New bone marrow image dataset powers AI to spot dysplastic cells and improve diagnosis of blood cancers.

A pilot study shows that yoga and walking for type 2 diabetes significantly improve blood glucose outcomes, especially when combined.

Transepidermal water loss monitoring lowered anaphylaxis rates and reaction severity during peanut oral food challenges, offering a potential tool to improve diagnostic safety.

A novel cross-frequency brain stimulation approach (cf-tACS) boosts stroke rehabilitation, restoring visual motion processing and improving visual field deficits in adults.

The study also identified a significant excess of ultrarare regulatory variants associated with cardiomyopathy, arrhythmia, and epilepsy genes.

Low PlGF precisely predicts early pre-eclampsia risk in sickle cell pregnancies, greatly improving maternal outcomes.

Medicare data show RSV infection may trigger Guillain-Barré syndrome in older adults, although rare. Clinicians should remain vigilant in high-risk populations.

Survivors of SJS/TEN report lasting physical, psychological, and social effects, with major gaps in post-discharge care and support highlighted in a new qualitative study.

Study shows in-office transperineal prostate biopsy under local anaesthesia achieves high diagnostic accuracy without antibiotics.

A new study shows that long sustained-attention tasks detect fatigue in people with multiple sclerosis far more effectively than short cognitive tests.

Importantly, the study highlighted that individual responses to orange juice can vary according to body mass index.

Maternal use of inhaled corticosteroids during pregnancy improves early lung function in infants born to asthmatic mothers. This intervention may reduce early respiratory risk.

A study in young adults shows that ultra-processed foods increase the risk of prediabetes and insulin resistance. Limiting ultra-processed foods may help prevent type 2 diabetes.

Semaglutide 2.4 mg/week reduced liver fibrosis and resolved MASH in the ESSENCE trial, offering dual hepatic and metabolic benefits.

Childhood hypertension affects millions worldwide, with prevalence nearly doubling from 2000 to 2020, new analysis shows.

A large cohort study shows that AMH levels do not affect perinatal outcomes in women with PCOS undergoing fresh or frozen embryo transfer.

Antibiotic-resistant infections surge in the UK, with nearly 400 weekly cases reported in 2024 and rising deaths, UKHSA report reveals.

A new study finds many balloon sinus dilation patients undergo the procedure without a recent preoperative CT scan, raising concerns about safety and adherence to guidelines.

Researchers demonstrate how cross-modal imaging can noninvasively identify histologic features of skin, advancing precision in dermatologic diagnosis.

Large umbrella review finds no clear link between maternal paracetamol use during pregnancy and autism or ADHD in children.

A major UK study of 309,000 adults links better sleep quality to a lower risk of developing migraines, partly explained by healthier cholesterol levels.

New study reveals how lifestyle, goals, and convenience shape diabetes patients’ diet choices, guiding better patient-centred advice.

While further large-scale trials are needed, this precision-based treatment represents a promising advance in managing atopic dermatitis.

New European research reveals that remission in autoimmune hepatitis does not guarantee recovery, with many patients reporting fatigue and poor quality of life.

A first-of-its-kind clinical trial finds that moderate coffee consumption may actually protect the heart, reducing AF recurrence risk.

Doctors reported the first case of healthy twin girls born after transfer of three aneuploid embryos screened by PGT-A during IVF.

Early changes in the nasopharyngeal microbiome could signal fatal infections in infants, offering hope for precision diagnosis and care.

A major cohort study involving over 20 million patients found that seborrheic dermatitis was significantly associated with several epithelial barrier diseases.

A major clinical trial shows high-dose fish oil significantly reduces cardiovascular events in haemodialysis patients, offering a promising new preventive strategy.

Remimazolam offers a rapid onset and offset, cardiovascular stability, and organ-independent metabolism, making it especially suitable for older patients.

New research reveals that abnormal chest X-ray results strongly predict future TB risk, emphasising the value of early screening.

By demonstrating that targeted molecular editing can reverse memory loss in ageing brains, this research opens an entirely new direction for therapies.

By integrating PAE into standard hospital practice, this initiative aims to reduce inaccurate allergy labels with the aim of lowering antibiotic resistance.

A large U.S. study finds people with seborrhoeic dermatitis are more likely to develop other barrier-related diseases, supporting the epithelial barrier theory.

Mazdutide, a dual GLP-1 and glucagon receptor agonist, significantly reduced liver fat and improved metabolic markers in people with MASLD and obesity.

A new meta-analysis shows chocolate milk significantly lowers serum lactate after exercise, outperforming other recovery drinks, especially in endurance athletes.

New Danish research shows a slightly higher endometrial cancer risk in women with an insufficient endometrial biopsy compared to normal samples.

Only 18 asymptomatic H5N1 cases have been reported globally; most found via enhanced surveillance of high-risk contacts.

A UK online trial found that daily and weekly bathing make no difference to eczema symptoms.

A major clinical trial shows that a conservative, indication-based dialysis strategy improves kidney recovery and reduces complications in acute kidney injury.

A European survey of 470 clinicians shows major differences in how LAMAs are prescribed for severe asthma.

New research shows no clear link between diet, urinary pH, and recurrent UTIs in postmenopausal women. Learn more about this pilot study’s findings.

Genomic profiling revealed druggable targets in 39% of advanced prostate cancer cases, guiding personalised treatments.

Researchers highlight early diagnosis and tumour type differences as key factors improving outcomes in testicular cancer.

IURES 2025 study supports transperineal prostate biopsy under local anaesthesia as a safe, effective diagnostic option.

A U.S. study finds that lower-body fat protects against type 2 diabetes, while abdominal fat increases risk, especially among men.

Researchers at IURES 2025 report seminal vesicle sampling enhances diagnostic accuracy in transperineal prostate biopsies.

Research consistently shows that epinephrine is underused, with many patients instead receiving antihistamines or steroids despite these offering only supportive relief.