Allergy & Immunology

Very low-dose multi-nut oral immunotherapy significantly increased tolerance in children with multiple nut allergies, with a favourable safety profile and no epinephrine use.

A new ANAcare pathway offers clinicians practical, harmonised steps to apply the latest guidelines for diagnosing IgE-mediated food allergy.

A new US Drug Allergy Registry report outlines standardised paediatric antibiotic allergy testing protocols to curb unnecessary labels and harmonise research.

A new BSI-CIPN report warns that UK clinical immunology and allergy services are critically understaffed, calling for urgent national workforce planning and investment.

A rare case of ABPA presenting as pyopneumothorax highlights the need for early recognition of pleural complications in asthmatic patients.

Blood proteomics uncovers systemic immune changes across inflammatory skin conditions.

Depression and anxiety increase asthma attack risk in adults, highlighting need for targeted care in those with comorbid mental health disorders.

A French national study has identified eight emerging food allergens frequently causing anaphylaxis but not included in EU labelling rules.

A new milk allergy therapy protocol lowers the severity of gastrointestinal reactions during OIT, improving safety for patients.

A 10-year study shows allergen immunotherapy provides lasting symptom relief in local allergic rhinitis and reduces the risk of asthma and new sensitizations.

A newly reported fatal case of delayed anaphylaxis following beef consumption highlights the growing impact of alpha-gal syndrome.

Transepidermal water loss monitoring lowered anaphylaxis rates and reaction severity during peanut oral food challenges, offering a potential tool to improve diagnostic safety.

While further large-scale trials are needed, this precision-based treatment represents a promising advance in managing atopic dermatitis.

By integrating PAE into standard hospital practice, this initiative aims to reduce inaccurate allergy labels with the aim of lowering antibiotic resistance.

A large U.S. study finds people with seborrhoeic dermatitis are more likely to develop other barrier-related diseases, supporting the epithelial barrier theory.

Research consistently shows that epinephrine is underused, with many patients instead receiving antihistamines or steroids despite these offering only supportive relief.

A multicentre, randomised, controlled trial evaluated the efficacy and safety of integrating nasal saline irrigation with Aze-Flu nasal spray.

The relationship between allergic rhinitis and optic neuritis appears to involve shared inflammatory pathways.

Discover a study on drug provocation tests in mastocytosis, revealing how they safely identify tolerable medications and reduce the risk of severe hypersensitivity reactions.

A recent study examined 36 months of peanut sublingual immunotherapy in children aged 1–4 years, assessing both desensitisation and remission outcomes.

Patients with elevated TSLP may represent a unique target population for specific therapies, including biologics that modulate Type 2 inflammation.

The JECS cohort followed more than 88,000 newborns across Japan, assessing allergic conditions from birth to age four.

These declines were observed regardless of atopic dermatitis diagnosis, indicating that early food introduction benefits both high-risk and general populations.

This paradoxical effect appears to be context-dependent, influenced by factors such as infection, allergen exposure, and systemic stress.

The study found that urinary øLT levels were significantly elevated, four- to five-fold higher, in patients with severe asthma compared to healthy controls.

Enhancing PPIE in allergic disease research offers tangible benefits, from improving patient outcomes to ensuring studies align with real-world needs.

The review revealed that patients consistently prioritise rapid symptom relief, preferably within two weeks, alongside long-term control of hives, itching, and swelling.

The study found that pectin treatment improved Pru p 3 tolerance in over half of participants, with 30% achieving full tolerance to the equivalent of a whole peach.

A study reveals that vitamin C supplementation during pregnancy in smokers influences asthma-related DNA methylation in children. This epigenetic change supports better lung health at 5 years.

Discover a study showing how baked milk intake accelerates cow’s milk allergy resolution, boosting safety and tolerance in young children.

The study’s objective was to assess the safety of a two-step direct challenge (DC) to amoxicillin, crucially performed without preceding skin testing.

A major new study has provided evidence that treatment for childhood asthma could be significantly improved by replacing traditional salbutamol relievers with budesonide–formoterol.

Food allergies are now considered the “second wave” of the allergy epidemic, following asthma, and they disproportionately affect infants and young children.

Lateral flow Enhanced by Optical imaging combines the proven lateral flow assay platform with advanced smartphone-based image analysis.

Findings revealed that 17 allergens, already part of the adult EBS, produced positive reactions in at least 1% of children.

Large-scale surveys, such as those conducted by the University of Chicago, align with these findings, reporting crustacean allergy prevalence of around 1.2%.

Previous research has shown that blueberry intake in adults increases beneficial Bifidobacterium species, enhances gut barrier integrity, and reduces inflammation.

Discover a study exploring how AI can transform allergy and immunology, highlighting challenges, opportunities, and a roadmap for clinical impact.

Discover a study exploring how a traditional Chinese herbal formula significantly reduced symptoms of seasonal allergic rhinitis with minimal side effects.

Learn how omalizumab shows high response rates and low side effects in children with chronic spontaneous urticaria.

A recent mixed-methods study evaluated NOURISH-US, a revised food-supplement programme designed to ease costs for households with a child aged 12 or younger managing any food allergy.

Discover a study showing how early milk exposure accelerates tolerance in children with CMPA.

Tezepelumab reduces exacerbations and enhances lung function and quality of life in severe, uncontrolled asthma.

Against this backdrop, the gut–lung axis has emerged as a persuasive framework for understanding disease heterogeneity.

This study evaluated a clustered nursing care model, delivered via an online platform, for adults with atopic dermatitis.

Both groups demonstrated significant improvements over pretreatment at every follow-up, one week, one month, three months and six months.

In a prospective study measuring the 14 most abundant HMOs in colostrum and at three months postpartum, researchers tested whether maternal supplementation with ω-3 polyunsaturated fatty acids alters HMO profiles.

Two new studies have identified cysteinyl leukotrienes as key drivers of food-allergy-induced anaphylaxis in mice.

Language barriers lead to worse outcomes in patients with asthma, with poorer lung function, a higher risk of uncontrolled asthma, and more emergency department visits, highlighting the need for culturally and linguistically appropriate care.

Excerpt: New research reveals that pore-forming proteins in common allergens perforate airway cells, triggering immune responses that lead to respiratory allergies. This discovery uncovers a shared mechanism behind diverse allergens and offers potential new targets for allergy treatment.

Find out more about peanut oral immunotherapy as a promising treatment for young children in Australia with peanut allergy.

These findings support the effectiveness of herbal-based emollients plus in managing atopic dermatitis, extending beyond simple hydration to actively aiding in barrier repair and symptom relief.

The BTCRC LUN 16-081 trial is the first to evaluate a shorter, six-month course of consolidation immunotherapy using nivolumab alone or in combination with ipilimumab.

The study found that patients receiving the AR-PRISE intervention experienced significant improvements in symptom control, particularly over the longer term.

The study also highlighted the diagnostic challenges posed by unreliable histories and overlapping symptoms from infection-related exanthems.

Peanut oral immunotherapy (POIT), which involves gradually increasing exposure to peanut protein, has shown promise, successfully desensitising 50–70% of patients.