Flagship Journal

This article summarises an Orchard Therapeutic-sponsored symposium titled ‘New horizons for metachromatic leukodystrophy – with the advent…

Altered gut microbiome profiles correlate with anxiety and depression in humans, and work in animal models has identified specific…

The human body is a holistic system, interconnected by the circulatory, nervous, lymphatic, endocrine, and immune systems that facilitate…

The upper gastrointestinal microbiome, a complex ecosystem of microorganisms that have historically been difficult to identify, may play a…

Multifocal motor neuropathy (MMN) is a rare immune-mediated disorder characterised by progressive, asymmetric muscle weakness…

An acute necrotising myopathy is a distinct form of uncommon muscle disease characterised by the rapid advancement of weakness affecting…

Peritoneal tuberculosis (TB) is a form of extrapulmonary TB that primarily affects areas such as the omentum, liver…

A recent randomised controlled trial came to the surprising conclusion that dual gonococcal treatment with azithromycin/ceftriaxone…

Following an admission to the authors’ centre with severe anaemia, duodenal biopsy confirmed the diagnosis of Whipple’s disease…

A summary of the latest ozanimod data presented at UEGW and ACG 2024, confirming the continuing long-term efficacy and safety profile of…

It takes an interdisciplinary approach to solve complex problems in the microbiome because you couldn’t ask for a more complex system.

Our key discoveries range from epidemiologic evidence on breastfeeding and chronic disease prevention to mechanistic research on breast milk compounds and the infant microbiome.

Preterm premature rupture of the membranes (PPROM) impacts 5–7% of all pregnancies. A pregnancy is considered previable, the fetus having…

This article summarises a LivaNova-sponsored symposium entitled ‘The Power of Real-World Evidence with CORE-VNS’, delivered on 7th…

IgA nephropathy (IgAN) can impact life expectancy in those affected, thus efficacious treatment is key. Endothelin 1 (ET-1) and angiotensin…

Fertility rates have reached the lowest level in recent years all over the world, even in traditionally overpopulated nations such as…

The editor’s pick for this issue is a review article discussing the promise of hyperpolarised xenon MRI, a non-invasive imaging technique…

Type 2 inflammation is involved in severe asthma (SA), chronic rhinosinusitis with nasal polyps (CRSwNP), and eosinophilic granulomatosis…

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity, which commonly presents with…

Tuberculosis (TB) represents a significant global public health issue, ranking as the 13th leading cause of mortality and standing as the…

Radiographic axial spondyloarthritis (r-axSpA), formerly known as ankylosing spondylitis (AS), is a chronic inflammatory disease that…

Human papillomavirus (HPV) is a sexually transmitted infection linked to genital, anal, and oral warts, as well as cervical and other…

Tuberculosis (TB) is caused by the bacteria Mycobacterium tuberculosis, a complex, rod-shaped, non-spore-forming, thin, aerobic bacterium…

The uncus is a hook-shaped structure located on the most anteromedial aspect of the parahippocampal gyrus, which is part of the medial…

Leiomyomas or fibroids are the most frequently encountered benign neoplasm of smooth muscle origin in women of reproductive age…

Non-steroidal anti-inflammatory drugs (NSAID) are useful in treating musculoskeletal disorders, headaches, pain, fever, and others…

Looking back to the year 2000, we were very divided across the world in understanding PCOS. The Americans had a different definition from…

Advances in Therapy to Address Proteinuria in Patients with Immunoglobulin A Nephropathy. As the majority of patients with IgA…

Hyperpigmentation disorders, a group of common skin conditions characterised by darkened patches due to excess melanin production, affect…

Osteoarthritis (OA) is the most common arthritis worldwide, causing pain, disability, and loss of function due to chronic joint disease​​…

Gadolinium is an invaluable contrast agent in MRI that has various important benefits in radiology. Its unique magnetic properties allow…

COVID-19 is a novel β-coronavirus caused by infection with SARS-CoV-2. It is the third zoonotic disease caused by coronavirus to affect…

The worldwide prevalence of benign prostatic hyperplasia (BPH) varies between 20–60% in men over 50 years. Similarly, about 50% of men…

A brain tumour develops as a result of abnormal cell growth in the brain. Tumours are classified as malignant or benign. Malignant tumours…

Obstructive sleep apnoea (OSA) is a complex and chronic disease characterised by loud snoring, daytime sleepiness, and witnessed breathing…

Gynaecomastia, the clinical term for the enlargement of the male breast, is characterised by the histological finding of…

Tuberculosis is a well-known endemic disease in India; however, extra-pulmonary tuberculosis in the form of single parotid gland…

Vasculogenic female sexual dysfunction syndromes affect millions of ageing women worldwide, whose day-to-day symptoms of coital…

This study investigates the impact of extracapillary proliferation in proliferative lupus nephritis on remission rates in patients.

This article reviews real-world data presented at the ADA Scientific Sessions 2024. It demonstrates the glycaemic range when Control-IQ Technology users do not manually bolus for extended periods

I have worked previously in healthcare management consulting, health services research, clinical practice, and healthcare administration…

For clinical applications of AI, it’s still early; most are unlikely to be found at the patient’s bedside and are still in the research…

The rare diseases Duchenne and Becker are X-linked recessive neuromuscular disorders.1 They are characterised by progressive…

Climate change is happening, with the evidence clearly demonstrating an increase in global temperatures; extreme weather events…

Nebulisers are devices used to rapidly deliver high doses of medication to the lungs in people with respiratory disease…

One in 10 people may be affected by a rare disease (RD) in their lifetime.1 This is the surprising paradox of RDs. While each disease…

Children diagnosed with congenital heart disease (CHD) have an increased risk of developing neurodevelopmental disabilities…

Zinc salts are one of three approved treatments for the autosomal recessive condition Wilson’s disease (WD). Their use was first described…

A previously healthy 17-year-old male was transferred from a community hospital to the authors’ tertiary paediatric emergency department…

Dermatitis artefacta (DA), also known as artefactual skin disease, is a rare psychocutaneous disorder characterised by…

Nipah virus disease is a zoonotic infection caused by the Nipah virus (NiV) of the Genus Henipavirus of the Paramyxoviridae family…

Erection is a neurovascular response accompanied by the release of neurotransmitters. The penis is innervated by autonomic (sympathetic…

Infection leads to an increased rate and duration of hospitalisation, increased treatment costs, and high morbidity and mortality in…

Severe cutaneous adverse drug reactions (SCAR) are a group of rare but potentially life-threatening conditions that can occur in response…

Superior vena cava syndrome (SVCS) is a group of clinical manifestations, caused by an obstruction of venous blood flow to the heart…

Dr Enrique Casado and Professor Lothar Seefried talk about the of early identification of individuals at risk of osteoporosis fractures…

Maternal and fetal outcomes associated with the authors’ approach of Caesarean hysterectomy for placenta accreta spectrum disorders…

I always knew that I wanted to work with children. My mother is a paediatric nurse practitioner, and my father is a child psychiatrist…

In patients with immunoglobulin A nephropathy, use of the endothelin 1 Type A/Ang II subtype 1 receptor antagonist sparsentan can decrease proteinuria and preserve kidney function

Targetted prophylaxis is recommended for people with HAE, but many remain on attenuated androgens. EMJ spoke to two HAE experts who explain how they help patients to make the switch.

Emer Kelly. Respiratory Consultant and General Physician, St. Vincent’s University Hospital, Dublin, Ireland. I had asthma as a child, so…

Kiley Whalen. Physician Assistant, Adirondack Rehabilitation Medicine; Master of Science in Physician Assistant Studies at the Center for…

Methotrexate (MTX), an antimetabolite, has a multifarious mechanism of action that most notably includes folate antagonism, effects on…

Cervical cancer is established as a major cause of morbidity and mortality among females globally.1 In Kenya, and other countries with…

End-stage liver disease (ESLD) represents a non-reversible, advanced stage of cirrhosis, where the hepatic architecture is distorted and…

Endoscopic retrograde cholangiopancreatography (ERCP) includes specialised techniques, such as sphincterotomy, balloon dilation…

Smeeta Sinha National Clinical Director for Renal Medicine, NHS England, UK; Consultant Nephrologist, Northern Care Alliance NHS Foundation…

After being diagnosed with cancer, patients embark on a journey that involves ongoing treatments, and regular visits to healthcare…

Patients with chronic kidney disease (CKD), especially those on chronic haemodialysis (HD), have a higher incidence of nosocomial…

Multiple myeloma (MM) is a disease characterised by the clonal expansion of malignant plasma cells in the marrow, leading to anaemia…

Sickle cell disease (SCD) is a genetic condition caused by mutations in the haemoglobin (Hb) gene, resulting in various complications. One…

HIV is an epidemic in Kenya. Females living with HIV (FLHIV) have an eight-fold increased risk of a pregnancy-related death compared to…

I am interested in family medicine and primary healthcare because primary healthcare is the first gatekeeper in the community…

Mycobacterium tuberculosis causing glomerulonephritis (GN) is a rare occurrence, and its association has been seldom reported…

IgAN, which can lead to CKD and kidney failure, is the most common form of primary glomerulonephritis, predominantly…

Many patients experience impairment following a stroke, including motor or cognitive impairment, urinary incontinence, dysphagia…

First described by German physician Peter Emil Becker in the 1950s, Becker is an X-linked genetic recessive disorder. Like Duchenne…

Methotrexate is a common first-line treatment for rheumatoid arthritis, yet its widespread and habitual usage often leads physicians…

While awareness of the issues facing women leading up to, during, and following the menopause has increased in recent years…

Renal cell carcinoma (RCC) is the most common primary tumour originating from the kidney, and accounts for more than 90% of all renal…

Obesity is a major risk factor for the development of Type 2 diabetes (T2D), with the prevalence of both increasing in a parallel manner…

The optimal dressing is still unclear, despite hypospadias being one of the most prevalent surgical operations. Children’s dressing for…

A spontaneous subcapsular hepatic haematoma (SHH) is both a rare and potentially life-threatening condition. Although the pathogenesis of…

One of the many extra-hepatic manifestations of hepatitis B virus (HBV) infections is vasculitis. While the classic HBV-associated…

Obesity, defined as a BMI greater than or equal to 30 kg/m2, is a condition with rising incidence around the world that contributes…

When I started out way back in the 1980s, addiction was predominantly dealt with by psychiatrists in hospitals, psychiatrists…

Leprosy, also known as Hansen’s disease, is a chronic granulomatous infection. It is non-fatal and slowly progressive. Its causative…

This continuing medical education-accredited symposium, held at the 2023 International Society for Thrombosis and Haemostasis (ISTH)…

The deficiency of arylsulfatase A due to the mutations in the ARSA gene is the cause of a rare inherited lysosomal storage disease…

With a pre-specified aim of improving the standard of care of those living with intermittent catheter use, a roundtable discussion led by…

The climate crisis is a health crisis that has the potential to cause significant morbidity and mortality to human populations…

It is essential to address psychological health, particularly post-traumatic stress disorder (PTSD), among patients who have recovered from…

The first thing is probably the holistic approach to care. Primary care provides care for people for a large part of their life…

Obesity has become a serious public health issue worldwide, with its prevalence steadily increasing. The potential consequences of this…

Vitiligo is an autoimmune disorder characterised by the loss of melanocytes, resulting in white, depigmented cutaneous macules…

This study examines the interrelationships between macroeconomic factors, inflation and vaccination rates, and ranks countries’ efficiency in combating the pandemic based on their health-economic factors.

There are two major categories of lung functional disorders, including restrictive and obstructive lung diseases. Restrictive lung disease…

I undertook my university courses at University Hospitals, and at several other hospitals in Belgium, but I also had some training in…

Tuberculosis (TB), rightly referred to as an ancient disease, has affected humans for thousands of years, the first drafted reference…

My interest in cancer research was sparked during my experience in the Undergraduate Research Opportunity Program (UROP) as an…

Chronic kidney diseases (CKD) are very prevalent in Central America, particularly in El Salvador. Mesoamerican nephropathy (MN) is a CKD diagnosis that almost exclusively affects young male agricultural labourers.

This review of the ‘Elevating Aesthetics’ symposium held at the International Master Course on Aging Science (IMCAS) 2023 shares insights…

Any haemoptysis exceeding 100 mL/hr, causing abnormal gas exchange/airway obstruction or leading to haemodynamic instability is defined as life-threatening or massive haemoptysis…

Lupus enteritis is a rare and poorly understood cause of abdominal pain in patients with systemic lupus erythematosus (SLE)…

A spectrum of various pathophysiological processes associated with a progressive worsening in estimated glomerular filtration rate (eGFR)…

Carbapenem-resistant Enterobacteriaceae (CRE) is defined as Enterobacteriaceae that are resistant to the carbapenem group of antimicrobials.

Cutaneous squamous cell carcinoma (SCC) contributes to 20% of non-melanoma skin cancers and early diagnosis is vital to reducing…

Initially, I was student in endocrinology; however, after some years, I understood that the holistic approach to complex patients…

General practices in the UK are under immense pressure. Research has been conducted on the complexity of current consultations ​and the use of electronic consultations…

I was inspired to go into geriatric medicine in the late 1980s and early 1990s, when I was a registrar in medicine in Newcastle, UK. I worked with some truly inspirational geriatricians at the time, which I think was a major factor in my decision.

Iron deficiency anaemia (IDA) is a global health problem affecting both developing and developed countries, particularly in Asia. Nutritional deficiency, menstrual blood loss, and chronic gastrointestinal blood loss are the common causes of IDA.