Articles

Since their introduction in 2001, tyrosine kinase inhibitors (TKIs) targeting BCR-ABL have become the standard therapy for chronic myeloid leukaemia (CML).

Endoscopic endonasal surgery has become a standard procedure for functional treatment of benign pathologies. Materials and improved surgeon skills have…

Breast cancer is one of the deadliest cancer types worldwide and consists of several subtypes differing in their molecular characteristics; each subtype…

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract, arising from the interstitial cells of…

Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid disorders. Allogeneic stem cell transplantation (alloSCT) is the therapeutic approach…

The occurrence of bladder outlet obstruction (BOO) in men with prostate cancer is common. Although relieving the obstruction may not change prognosis, it…

Epstein-Barr Virus (EBV), or more commonly known as the ‘kissing disease’ is seemingly unavoidable within the adolescent and teenage community.

Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit. AV has a multifactorial pathogenesis with specific roles played by the…

Stevens-Johnson syndrome and toxic epidermal necrolysis are among the most concerning drug reactions affecting adults and children. Although the overall…

Acne vulgaris is one of the most common skin diseases in the world. There are many factors involved in its pathogenesis. The dermatosis is characterised…

Leprosy is a model disease for understanding human immune responses underlying diseases caused by intracellular pathogens, as well as providing valuable…

Background: The face is the most common site affected by skin cancer in the body and of the facial skin it is the nose that bears the brunt of the attack.

Background: The neonatal period is a phase of adaptation during which several skin conditions can develop. Most of these findings characterise the…

Brucellosis is a zoonotic infectious disease of worldwide distribution and is still endemic in some developing countries. Brucellosis is a systemic…

As innovation catalyses the potential for personalised medical diagnosis and treatment the English National Health Service (NHS) moves to embrace these…

There is growing evidence indicating the effects of medications for Type 2 diabetes mellitus (T2DM) on bone metabolism and fracture risk.

The majority of patients with Type 2 diabetes require insulin therapy for treating hyperglycaemia. There are several regimens available for insulin…

Gestational diabetes mellitus (GDM) is a major public health problem with various complexities involved in its diagnosis. Traditionally an oral glucose…

Chorioretinal vascular diseases are among the leading causes of blindness in industrialised countries. The recent development and widespread adoption of…

Moringa oleifera leaf powder (MOLP) was incorporated into patient diets in order to study its effects on the levels of fasting blood glucose (FBG)…

To evaluate the prevalence of chronic respiratory symptoms, lung function impairment, and chronic obstructive respiratory diseases in crop farmers. Our…

We report a case of systemic lupus erythematosus in a 27-year-old female complicated with pneumonia and severe respiratory failure, requiring treatment…

Smoking is the leading cause of lung cancer (LC) worldwide, however any continuing effects of smoking or cessation following a diagnosis are less well…

Major changes are bringing a new dimension to thoracic surgery and lung transplantation. This article reports the foremost recent advancements within the…

Pneumoconiosis as an occupational disease is a serious threat to the health of workers. Patients with pneumoconiosis are mainly engaged in dust-related…

The success and evolution of video-assisted thoracic surgery (VATS) renewed the interest for thoracoscopic operations in awake patients. Non-intubated…

Comorbidities are common in chronic obstructive pulmonary disease (COPD). Cardiovascular comorbidity is a leading cause of morbidity and mortality in…

The original Fontan procedure was first introduced in the 1970s. The concept behind this surgical technique was revolutionary. It has subsequently…

Although there have been marked improvements in both diagnostic and therapeutic interventions over several decades, coronary artery disease (CAD) remains…

An elderly hypertensive lady presented to us with acute coronary syndrome; an angiogram revealed total thrombotic occlusion of large left circumflex…

Coronary artery spasm is an abnormality of coronary vascular smooth muscle contraction that is associated with significant morbidity and mortality. The…

Heart valve disease is a very common medical condition; the most frequent aetiology is degenerative valve disease, mainly represented by calcific aortic…

This case report describes a 27-year-old pregnant woman with a gestational age of 26 weeks and 3 days who developed cardiac arrest in her home…

Chest pain and coronary artery disease (CAD) impose a substantial burden on public health and society. Diagnostic imaging tests are used by clinicians to…

Benign prostatic hyperplasia (BPH) is common in men aged >60 years, affecting urinary and bladder function. Due to the progressive nature of the disease…

Imagine. When you are well, the last thing you have on your mind is your health. We all take feeling normal for granted. When we feel right, all is fine.

Patients of any age with a serious progressive illness and a limited life expectancy that ranges up to a few years can be managed by palliative care.

The scope of this short review is to discuss the current state of practice in detection and removal of sessile serrated polyps (SSPs) during…

The evaluation of patients with fibromyalgia (FM) and other functional somatic syndromes can appear intimidating, but a high index of suspicion and a…

The main objectives of erectile dysfunction (ED) management are to control and reduce associated organic cardiovascular risk factors and to restore the…

Chronic cystitis may be due to different known causes. Current basic science research has revealed a wide consensus that chronic cystitis may arise from…

On January 14th 2016, SB4 (Benepali®) received marketing authorisation application approval from the European Commission (EC). It is the first biosimilar…

Stent thrombosis is a life-threatening complication of percutaneous coronary intervention that often results in ST-segment myocardial infarction or …

The term spondyloarthritis (SpA) is used to describe a heterogeneous group of diseases sharing certain characteristics.

Stress urinary incontinence (SUI) in women is an endemic and costly problem. It is associated with a significant burden on both a personal and community…

Cirrhosis is the final stage of chronic liver disease and has many causes, including viral hepatitis, excessive alcohol intake, and non-alcoholic…

Although carotid artery stenting is a safe and effective treatment for preventing ischaemic stroke in significant carotid atherosclerotic disease, it can…

Liver cirrhosis represents a severe complication for hepatitis C patients. Patients with cirrhosis require immediate treatment; a sustained virological…

Within 10 years following a coronary artery bypass graft (CABG), only 60% of vein grafts and 90% of internal mammary artery (IMA) grafts remain patent.

Pelvic inflammatory disease (PID) disproportionately affects adolescent and young adult (AYA) females and can negatively impact their short and long-term…

Fetal macrosomia is associated with a number of health complications for both mother and infant in the immediate, short, and long-term. Maternal obesity…

There has been an increase in the incidence of prostate cancer over time, and it now constitutes 15% of all male cancers in…

The progesterone vaginal ring (PVR) Progering® has been shown to be effective as a contraceptive in breastfeeding women who need safe and effective…

Lipschütz ulcers (LU) are acute genital ulcers that occur in women. These ulcers are painful and cause enormous emotional stress to the affected person…

Assisted reproductive technology (ART) is associated with an increased risk of monozygotic twinning. This narrative review attempts to summarise the…

A 42-year-old primigravida was admitted to the delivery suite for induction of labour at term due to gestational diabetes and pre-eclampsia. Her booking…