Hematology

Ponatinib is indicated for the treatment of adults with chronic myeloid leukaemia (CML) who are resistant to dasatinib or nilotinib, are intolerant…

Anaemia is characterised by a decrease in the total amount of red blood cells (RBC) and haemoglobin (Hb) levels, reducing the volume of oxygen transported through the blood…

The American Society of Hematology (ASH) guidelines and the International Consensus Report (ICR) recommendations were first published in 2010 and 2011…

This symposium focussed on the recognition of, and treatment options for, high-risk AML. Prof Cluzeau considered universal or targeted treatment…

Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme which catalyses the oxidative decarboxylation of isocitrate to α-ketoglutarate…

Venetoclax is a potent, selective, oral inhibitor of B-cell lymphoma-2. It is approved in the USA in combination with azacitidine, decitabine…

Haematological disorders are predominant in the tropical and subtropical countries where major problems of sickle-cell disease (SCD) and thalassaemias…

The initial management of deep vein thrombosis is starting to happen in general practice.

Many cases of pneumonia clustered in the city of Wuhan, China, were reported in December 2019, and source tracing has showed Huanan Seafood Market, Wuhan, China, as the origin.

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder resulting from autoantibodies produced by B-cell derived plasma cells.

Osteopetrosis (OP) is a rare genetically metabolic bone disorder caused by severe impairment of osteoclast-mediated bone resorption.

Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially aggressive and life-threatening syndrome of overactive histiocytes and lymphocytes…

This review centres on the impact next-generation sequencing (NGS) can have on the current management of haemato-oncological diseases…

The Kite, a Gilead company, symposium “Beyond Clinical Trials in B-Cell Malignancies: What Real-World Experience Tells Us” took place as part of the 24th…

The Kite, a Gilead Company, symposium “CAR-T: From bed to bench and back again” took place during the 2019 meeting of the International Conference…

Prof Sehn opened the symposium with an overview of diffuse large B-cell lymphoma (DLBCL) focussing on key milestones in treatment developments…

The first case focussed on a 56-year-old female economist, who presented with abdominal discomfort that led to a CT scan evaluation where lymph node…

Acute chest syndrome (ACS) is an acute inflammatory lung injury that usually follows the vaso-occlusive crisis (VOC) seen in sickle cell disease (SCD)…

Myelodysplastic syndromes (mds) are a heterogeneous group of disorders defined by ineffective haematopoiesis and clonal instability with risk of…

In low-grade B-cell lymphomas, Reed Sternberg (RS)-like cells can be seen in follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and marginal zone lymphoma.

Pernicious anaemia (PA) is an autoimmune disease of multifactorial aetiology involving environmental and immunological factors. It is the most common cause of cobalamin deficiency anaemia worldwide.

Acute vaso-occlusive crisis and haemolysis characterise sickle cell disease. Rarely observed, ‘girdle syndrome’ is a situation in which vaso-occlusion…

Treatment decisions in chronic myeloid leukaemia (CML) are complex and require the evaluation of many factors at each stage of therapy…

Biologic drugs are transforming treatment of other hard-to-treat diseases beyond cancer, including multiple sclerosis, heart disease, asthma, and…

Treatment of MM requires a multifaceted approach using a combination of therapies targeting the several pathophysiological pathways involved in the…

Cord blood can be collected and stored from the placenta and umbilical cord following the birth of a new-born. It is replete with haematopoietic stem…

Thalassaemia is a hereditary cause of hypochromic microcytic anaemia resulting from defects in haemoglobin (Hb) production…

Specifically, this study examines the use of abdominal imaging, via an ultrasound or CT scan, to identify the aetiology of haematologic abnormalities…

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder that lessens the production of platelets. Despite treatments being available for ITP…

Dasatinib is a potent and efficacious second-generation oral tyrosine kinase inhibitor, frequently used for imatinib-resistant or intolerant BCR-ABL+…

Currently, there is no evidence-based consensus for the management of CML in pregnancy; therefore, clinical observations have become very important…

Even though there are recent sophisticated biomarkers to diagnose sepsis, it is still challenging to curtail sepsis mortality by timely intervention…

Prof Salles provided an update on the ongoing first-line follicular lymphoma (FL) studies, demonstrating how analysis of the GALLIUM study data regarding…

Immunotherapy has revolutionised the treatment of haematologic malignancies. Patients with relapsed/refractory non-Hodgkin’s lymphoma have poor response…

Acute myeloid leukaemia (AML) is a disease with a very poor outcome and remains an area of significant unmet need, necessitating novel therapeutic…

Epstein–Barr virus (EBV) is one of the most important viral causes for the development of tumours. The global geographical epidemiology of EBV shows…

Although idiopathic aplastic anaemia (AA), myelodysplastic syndrome (MDS), and paroxysmal nocturnal haemoglobinuria (PNH) are all associated with…

The meeting was arranged as a series of conversations between experts, following a question and answer format with two speakers in each presentation…

The introduction of tyrosine kinase inhibitors (TKI) has dramatically improved the prognosis of chronic myeloid leukaemia (CML) patients and, therefore…

Although hypomethylating agents (HMA) have revolutionised the treatment of myelodysplastic syndromes (MDS), a significant proportion of patients either…

The humanised anti-CD20 antibody (Ab) rituximab (RTX) has significantly improved the prognosis of B cell non-Hodgkin’s lymphomas (BNHL). However, major…

Mycosis fungoides is the most common variant of cutaneous T cell lymphoma and frequently presents as early-stage disease with skin patches and plaques with an indolent course, but patients experience significant morbidity from itch and disfigurement.

Anaemia is the most widespread of the haematological disorders, affecting about one-third of the global population. Despite decades of public health…

Multiple myeloma is increasingly being recognised as more than one disease, characterised by marked cytogenetic, molecular, and proliferative heterogeneity.

β-thalassaemias are inherited blood disorders caused by a defect in the production of β-globin, giving rise to variable phenotypes.

Myelofibrosis (MF), either primary or secondary to polycythaemia vera or essential thrombocythaemia, is the most symptomatic and has the worst prognosis…

Hypereosinophilic syndromes are a group of disorders characterised by significant eosinophilia and organ damage.

Patients with refractory/relapsed (R/R) non-Hodgkin lymphoma (NHL) make up a very heterogeneous population with a poor life expectancy.

The objective of the symposium was to provide an overview of the current treatment landscape in terms of later-line therapy in metastatic CRC (mCRC) and to discuss the evidence for the various options available.

The main objectives of the symposium were to explore the current developments in the diagnosis and treatment of non-Hodgkin lymphoma (NHL).

The purpose of this review is to provide the haematologist with a working knowledge of the common inherited bone marrow failure syndromes (iBMFS)…

Chronic neutrophilic leukaemia (CNL), chronic eosinophilic leukaemia-not otherwise specified (CEL-NOS), and myeloproliferative neoplasm (MPN)…

Acute lymphoblastic leukaemia (ALL) in adults has a survival rate of 40–50% at 5 years, with a high relapse rate after first-line chemotherapy.

Spasmodic dysphonia (SD): what about it? That is the million-dollar question.

Ms Rosmarie Pfau detailed the challenges faced by patients with FL around the world, particularly a desire for improved quality of life (QoL) and…

Despite significant therapeutic advances in the treatment of patients with non-Hodgkin lymphoma (NHL), a significant proportion experience relapse or…

The main objectives of this symposium were to review the value of biosimilars in sustainable treatment for haematologic malignancies and to recognise the…

This symposium was dedicated to discussing BCR-ABL-positive chronic myeloid leukaemia (CML) and Philadelphia-positive acute lymphoblastic leukaemia (Ph+ALL)

There are ˜3,000 children, as well an additional ˜7,000 adults, diagnosed with acute lymphoblastic leukaemia (ALL) each year in the USA.

The actin cytoskeleton plays many important roles in the lifecycle of platelets, from biogenesis from megakaryocytes, to activation and clearance from…

The management of acute lymphoblastic leukaemia (ALL) remains challenging.

In 2016, an update on the classification of lymphoid neoplasm was published, and one of the modifications made focussed on B-cell lymphoma…

The myelodysplastic syndromes form a heterogeneous group of clonal disorders with an increasing incidence in the elderly population and an emerging…

Sickle cell disease is a genetic disorder caused by sickle haemoglobin. In many forms of the disease, the red blood cells can change shape upon…

Prof Munshi opened the presentation with a brief video highlighting the interaction of myeloma cells with the bone microenvironment…

Improved Clinical, Laboratory, Molecular, and Pathological (CLMP) 2017 criteria for myeloproliferative neoplasms (MPN) define the JAK2V617F trilinear…

The emergence of B cell receptor (BCR) kinase inhibitors has recently changed the treatment landscape in chronic lymphocytic leukaemia (CLL). The…

Non-transfusion-dependent thalassaemia (NTDT) is a rather broad term that encompasses a group of thalassaemia syndromes, most commonly β-thalassaemia…

Prof Robin Foà opened the symposium by highlighting how improving healthcare and an ageing population are increasing the burden on healthcare resources…

A recent symposium at the European Hematology Association (EHA) congress, chaired by Prof Eva Kimby, explored the changing paradigms in the treatment of…

Several rare haematological diseases are linked to bone marrow failure (BMF). This symposium provided the latest scientific insights into the different…

The treatment landscape for patients with multiple myeloma (MM) is constantly evolving. Over the past decade, the introduction of novel agents including…

Direct oral anticoagulants (DOAC) are used in several indications for the prevention and treatment of thrombotic events. As highlighted by data from…

Non-Hodgkin lymphoma (NHL) is the eighth most common malignancy worldwide. Diffuse large B cell lymphoma (DLBCL) is the most frequent subtype, accounting…

Inherited thrombocytopenias comprise a heterogeneous group of blood disorders with abnormalities in genes related to glycoproteins and adhesion molecules…

The next-generation sequencing era has repeatedly demonstrated that the amount of acquired somatic mutations in paediatric cancers can rarely account for…

Less than 50% of patients with adult acute lymphoblastic leukaemia (ALL) experience long-term survival and for those adults >60 years old, long-term…

Sickle cell disease (SCD) is the most common haemoglobinopathy worldwide and its frequency has steadily increased in Europe in the past decades. SCD is a…

Diabetes is a non-communicable disease (NCD) meaning that it often cannot be seen. After 20 years of living with Type 1 diabetes I am lucky to have no…

The 11th New Horizons in Haematology (NHH11) conference was moderated by Dr Sarah Jarvis, healthcare reporter and television presenter, and was delivered…

The meeting commenced with a talk from Prof Anna Falanga on the management of thrombosis in both onco-haematological and non-oncological diseases.

The meeting was introduced by Prof Robin Foà who spoke about the difficulties for patients Prof Foà opened the symposium by highlighting…

Prof Martin Dreyling opened the symposium by providing an overview of the current status of mantle cell lymphoma (MCL) and the current guidelines…

Multiple myeloma (MM) usually responds to treatment but is incurable. The clinical course is characterised, in most patients, by a series of remissions…

Subclinical hypothyroidism (SCH) is defined by elevated thyroid-stimulating hormone (TSH) levels in the presence of normal thyroxine (T4) levels.

There is a new guy on the block. A new guy in the guise of a book written by new-age men talking about their very own personal experiences of their…

The endeavours of physicians taxed with the problem of iron deficiency over the last 100 years have successfully eliminated this as an issue of…

The improvement of molecular biology technologies and the increasing number of researchers interested in inherited thrombocytopaenias (ITs) has led…

Bone marrow failure (BMF) is characterised by a reduction in the effective production of mature erythrocytes, granulocytes, and platelets by the bone…

Biologicals have revolutionised modern medicine by offering vital therapeutic options to treat or prevent complex, disabling, and life-threatening diseases.

Prof Zelenetz opened the symposium on the evolving front-line treatment options for follicular lymphoma (FL) and discussed the potential of novel agents…

The Alexion satellite symposium was introduced by Prof Pier Mannuccio Mannucci who provided an introduction to the history of thrombotic…

CD30-positive (CD30+) lymphomas are a heterogeneous group of hematological malignancies that share the same antigen. Over recent decades, advances…

While the standard of care for chronic lymphocytic leukaemia (CLL) leads to high overall response rates and a long progression-free survival, it can be…

Chronic lymphocytic leukaemia (CLL) is a clinically heterogeneous disease characterised by the accumulation/expansion of a clonal population of…

In the last decades, advances in the therapeutic management of multiple myeloma (MM) with new drug armamentarium and strategies have significantly…

Autologous stem cell transplantation (ASCT) is considered the standard of care for multiple myeloma patients aged <65 years with no relevant…

Patients diagnosed with myeloproliferative neoplasms (MPNs) often develop thrombotic events as an onset of symptoms or in evolution. The pathogenesis of…

Calreticulin (CALR), a Ca2+ binding protein mostly localised in the endoplasmic reticulum, regulates Ca2+ homeostasis, chaperones, and other proteins to…

In patients undergoing major surgical procedures, preoperative anaemia and perioperative allogeneic blood transfusion (ABT) have been linked to increased…

This year (2014) we are celebrating the 80th anniversary of Dr Maxwell Myer Wintrobe’s pioneer works, one of the most important contributions in clinical…

Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal disorder of haemopoiesis characterised by haemolytic anaemia, thrombophilia and variable…

Classical Hodgkin lymphoma (cHL) is a lymphoproliferative disorder hallmarked by a distinctive type of neoplastic cells, the Hodgkin and Reed/Sternberg…

Pain is defined, by the International Association for the Study of Pain (IASP), as an ‘unpleasant sensitive and emotional experience, associated with or…

Burkitt lymphoma (BL) is a highly aggressive B-cell malignancy, occurring with increased frequency among patients infected with HIV. For several years…

Therapeutic progress in aggressive myeloid malignancies such as acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and advanced…

Hypomethylation agents became the standard of care for patients with high-risk myelodysplastic syndrome (MDS). While long-term benefits of azacitidine…